Cadmium, lead and endometriosis

Objectives: Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown. Methods: We compared cadmium urinary excretion (CdU) and blood concentration of cadmium (CdB) and lead (PbB) in 119 patients with peritoneal endometriosis and/or deep endometriotic (adenomyotic) nodules of the rectovaginal septum and 25 controls. Results: The mean levels of cadmium in urine and blood did not differ among the groups. Women suffering from endometriotic diseases showed lower levels of PbB than controls. Conclusions: These data do not support a role for cadmium in the onset or the growth of endometriotic diseases but suggest a possible relationship with lead. Similar content being viewed by others

Blazka ME, Shaikh ZA (1991) Sex differences in hepatic and renal cadmium accumulation and metallothionein induction. Role of estradiol. Biochem Pharmacol 41:775–780 Donnez J, Nisolle M, Smoes P, Gillet N, Beguin S, Casanas-Roux F (1996) Peritoneal endometriosis and “endometriotic” nodules of the rectovaginal septum are two different entities. Fertil Steril 66:362–368 Donnez J, Van Langendonckt A, Casanas-Roux F, Van Gossum JP, Pirard C, Jadoul P Squifflet J, Smets M (2002) Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 54:52–58 Flanagan PR, McLellan JS, Haist J, Cherian G, Chamberlain MJ, Valberg LS (1978) Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 74:841–846 Foster WG (1992) Reproductive toxicity of chronic lead exposure in the female cynomolgus monkey. Reprod Toxicol 6:123–131 Garcia-Morales P, Saceda M, Kenney N, Kim N, Salomon DS, Gottardis MM, Solomon HB, Sholler PF, Jordan VC, Martin MB (1994). Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. J Biol Chem 269(24):16896–16901 Gerhard I, Runnebaum B (1992) [The limits of hormone substitution in pollutant exposure and fertility disorders]. Zentralbl Gynakol 114:593–602 Giudice LC, Kao LC (2004) Endometriosis. Lancet 364:1789–1799 Goyer RA (1997) Toxic and essential metal interactions. Annu Rev Nutr 17:37–50 Heilier JF, Verougstraete V, Nackers F, Tonglet R, Donnez J, Lison D (2004) Assessment of cadmium impregnation in women suffering from endometriosis: a preliminary study. Toxicol Lett 154:89–93 Heilier JF, Nackers F, Verougstraete V, Tonglet R, Lison D, Donnez J (2005) Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules. Fertil Steril 84:305–312 Henry RJ (1965) Clinical chemistry: Principles and technics. Harper and Row, New York Henson MC, Chedrese PJ (2004) Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 229:383–392 Institute of Public Health (IPH), 2005. Surveillance of the population’s exposition to heavy metals—epidemiological surveillance of the general population, http://www.iph.be/epidemio/epien/index12.htm (access date 10/11/05) Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB (2003) Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 9:1081–1084 Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H (2002) Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol 83:149–155 Klaassen CD, Liu J (1998) Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity. J Toxicol Sci 23(Suppl 2):97–102 Kleinbaum DG, Kupper LL, Muller KE, Nizam A (1998) Applied regression analysis and other multivariate methods. Duxburry Press, MA Lauwerys R, Hoet P (2001) Industrial chemical exposure guideline for biological monitoring. Lewis Publisher, Boca Raton Martin MB, Voeller HJ, Gelmann EP, Lu J, Stoica EG, Hebert EJ, Reiter R, Singh B, Danielsen M, Pentecost E, Stoica A (2002) Role of cadmium in the regulation of AR gene expression and activity. Endocrinology 143:263–275 Muntner P, Menke A, DeSalvo KB, Rabito FA, Batuman V (2005) Continued decline in blood lead levels among adults in the united states: The National Health and Nutrition Examination Surveys. Arch Intern Med 165:2155–2161 Nehru B, Kaushal S. (1992) Effect of lead on hepatic microsomal enzyme activity. J Appl Toxicol 12(6):401–405 Safe S (2003) Cadmium’s disguise dupes the estrogen receptor. Nat Med 9(8):1000–1001 Stoica A, Katzenellenbogen BS, Martin MB (2000) Activation of estrogen receptor-alpha by the heavy metal cadmium. Mol Endocrinol 14:545–553 Taupeau C, Poupon J, Treton D, Brosse A, Richard Y, Machelon V (2003) Lead reduces messenger RNA and protein levels of cytochrome p450 aromatase and estrogen receptor beta in human ovarian granulosa cells. Biol Reprod 68:1982–1988 Vahter M, Berglund M, Akesson A, Liden C (2002) Metals and women’s health. Environ Res 88:145–155 Waalkes MP, Liu J, Goyer RA, Diwan BA (2004) Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation. Cancer Res 64:7766–7772 World health organisation (WHO) (1992) Cadmium international programme on chemical safety, vol. 134 Environmental health criteria, WHO, Geneva World health organization (WHO) (1995) Inorganic lead international programme on chemical safety, vol. 165 Environmental health criteria, WHO, Geneva Wilhelm M, Ewers U, Schulz C (2004) Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine. Int J Hyg Environ Health 207:69–73 Acknowledgments This work was supported by a grant no. 3.4587.01 from the Fonds de la Recherche Scientifique Médicale, Belgium. The authors thank K. Rozenkranz, M.D., L. de Buyl M.D., A.-T. Ha, M.Sc., and R. Rousseau, M.Sc., for assistance with data collection. The authors are grateful to C. Gathy and T. Seminck for experimental assistance. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Heilier, J.F., Donnez, J., Verougstraete, V. et al. Cadmium, lead and endometriosis. Int Arch Occup Environ Health 80, 149–153 (2006). https://doi.org/10.1007/s00420-006-0114-7 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00420-006-0114-7