Non-hormonal targets for the medical treatment of endometriosis

Stefano Luisi, Valentina Ciani, Serena Pinzauti, Claudia Tosti, Lucia Lazzeri, Sandro Razzi, Errico Zupi, Felice Petraglia
In: Journal of Endometriosis · 2012 · vol. 4(2) , pp. 85–92 · doi:10.5301/je.2012.9409 · W2055977529
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper reviews non-hormonal therapeutic targets for endometriosis, focusing on agents that affect angiogenesis, inflammation, oxidative stress, proliferation, or apoptosis.

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Abstract

Endometriosis is a chronic condition characterized by growth of endometrial tissue outside the uterus. Common symptoms include dysmenorrhoea, dyspareunia, non-cyclic pelvic pain, and infertility. Endometriosis is often treated surgically upon diagnosis but with a higher rate of recurrence, suggesting that a combination of surgical and medical management might provide better outcomes. The primary goal of medical treatment is to interrupt the growth and activity of endometriosis lesions. Because of the chronic nature of this disease, long-term or repeated courses of medication may be required to control symptoms. Increasing knowledge about the pathogenesis of endometriosis at the cellular and molecular levels may give us the opportunity to use new pharmaceutical agents affecting angiogenesis, inflammation, oxidative stress, proliferation or apoptosis to prevent or inhibit the development of endometriosis.

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Condition tags

endometriosisdysmenorrheadyspareuniainfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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last seen: 2026-06-04T00:00:01.174412+00:00
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