Endometriosis: Use of a new CA 125 assay in the diagnosis of endometriosis*
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This study compared a new CA 125 assay to an older one for diagnosing endometriosis, finding the new assay slightly improved sensitivity and specificity but did not dramatically enhance detection.
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Abstract
Serum CA 125 concentrations are elevated in some women with endometriosis; however, the low sensitivity and specificity of the assay have made it impractical to use it as a diagnostic test for endometriosis. Recently a second-generation CA 125 assay has been developed. The purpose of this study was to compare serum CA 125 concentrations in women with and without endometriosis using both the older assay and the new CA 125 assay and to determine if the new assay concentration improves the clinical utility of CA 125 in the diagnosis of endometriosis. A total of 123 patients with endometriosis, pelvic pain or infertility were enrolled. Blood for CA 125 was drawn in the cycle preceding laparoscopy or laparotomy, and concentrations found by the older and newer assays were correlated with the patients' endometriosis stage using the revised American Fertility Society classification of endometriosis. The CA 125 concentrations determined by the new assay were highly correlated with concentrations determined by the older assay in patients with and without endometriosis (r = 0.96). The sensitivity and specificity were slightly improved using the new CA 125 assay; however, this assay did not dramatically improve detection of endometriosis.
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Cited by (28)
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- Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis 2022
- Serum kisspeptin levels in deep-infiltrating, ovarian, and superficial endometriosis: A prospective observational study 2022
- Correlation of CA-125 with different stages of endometriosis 2018
- Elevated CA 125 in a CASE of Leaking Endometrioma 2018
- Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis 2016
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Correlation between ovarian chocolate cyst and serum carbohydrate antigen 125 level and the effect of ultrasound‐guided interventional sclerotherapy on serum carbohydrate antigen 125 level 2014
- Endometriosis of the ovary 2013
- Retrospective evaluation of tumor markers in ovarian mature cystic teratoma and ovarian endometrioma 2012
- Chronic and Recurrent Pelvic Pain 2011
- Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis 2010
- Ultrasonography of pelvic endometriosis 2010
- Endometriosis for the Colorectal Surgeon 2010
- Evaluation of Serum CA 125 Levels in Patients with Pelvic Pain Related to Endometriosis 2007
- Evaluation of serum CA 125 levels in patients with pelvic pain related to endometriosis 2007
- Adolescent endometriosis 2002
- Three-year follow-up of [CA-125, CA 19-9, CA 15-3, SIL-2R, IL-6, IL-la, TNF-a, sCD8 and sCD4] levels in a woman with severe endometriosis 2000
- Chapter 5 Diagnosis of Endometriosis 1999
- Diagnosis of Recurrent Endometriosis 1999
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis 1998
- Levels of Antibodies to Transferrin and Alpha 2‐HS Glycoprotein in Women With and Without Endometriosis 1998
- Reproductive Disorders Associated With Pelvic Pain 1998
- Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis 1997
- Prevalence of Endometriosis in Adolescent Girls With Chronic Pelvic Pain Not Responding to Conventional Therapy 1997
- BASIC RESEARCH IN ENDOMETRIOSIS 1997
- Correlation of Basal Menses CA‐125 Levels and 6 Month Pregnancy Rates in Women Undergoing Treatments for Infertility Without Assisted Reproductive Methods 1997
- Colonic adenocarcinoma in a rhesus macaque (<i>Macaca mulatta</i>) 1996
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