Serum CA-125 levels in the diagnosis and management of endometriosis.
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Serum CA-125 levels increased with endometriosis severity and decreased after gonadotropin-releasing hormone agonist treatment, but were not related to treatment outcome.
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Abstract
The value of CA-125 for the diagnosis and management of endometriosis (EN) was investigated by assaying the marker in the serum and peritoneal fluid (PF) from patients with the disease in comparison with control subjects. Of women who underwent 270 consecutive laparoscopies, 81 with various stages of EN (18 stage I, 13 stage II, 35 stage III and 15 stage IV) and 38 with normal pelvic findings were studied. CA-125 serum values increased progressively in relation to the severity of the disease. The levels in stages III and IV EN were significantly higher (P less than .01) than in stages I and II or control patients. The latter two groups did not differ from each other. High CA-125 PF values were found in all the patients investigated. Twenty-two patients with EN were treated with a gonadotropin releasing hormone agonist for six months before second-look laparoscopy or laparotomy. CA-125 values decreased significantly after one month of medical treatment and remained unchanged during the course of therapy. No significant relationship was found in the outcome after therapy.
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Cited by (13)
- When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement 2019
- Biomarkers in Endometriosis 2018
- Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis 2016
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Endometriosis: The gynecologist's opinion 2012
- Endometriosis: Disease Classification and Behavior 2011
- The effect of endometriosis, cycle stage, lymphocyte suppression and pregnancy on CA-125 levels in peritoneal fluid and serum in baboons 2005
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis 1998
- Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis 1997
- BASIC RESEARCH IN ENDOMETRIOSIS 1997
- The Effect of C0 <sub>2</sub> Laser Laparoscopy for Treatment of Pelvic Endometriosis on Serum Concentrations of Antiendometrial Antibodies 1994
- 4 Markers for endometriosis 1993
- Multiple serum marker assay in the diagnosis of endometriosis 1992
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- europepmc
- last seen: 2026-06-13T06:22:48.782012+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:12:00.397535+00:00
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