Prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma: Experiences at three academic institutions

Huimin Bai, Bai H, Cao D, Dongyan Cao, Fang Yuan, Yuan F, Guihua Sha, Sha G, Yang J, Jiaxin Yang, Jie Chen, Chen J, Yue Wang, Wang Y, Zhenyu Zhang, Zhang Z, Keng Shen, Shen K
Gynecologic Oncology · 2016 · vol. 143(3) , pp. 526–531 · doi:10.1016/j.ygyno.2016.10.009 · PMID:27745918 · W2535842004
article OA: closed CC0 ⤵ 10 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-21 ⓘ

This study evaluated the prognostic significance of endometriosis in patients diagnosed with stage I ovarian clear cell carcinoma across three academic institutions.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectivesTo investigate the prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma (OCCC).MethodsThe medical records of patients with stage I OCCC who had undergone complete staging surgery followed by systemic chemotherapy were retrospectively reviewed.ResultsA total of 237 women were included in this study. Univariate analysis revealed that the patients with endometriosis-associated ovarian carcinoma (EAOC) had significantly improved recurrence-free survival (RFS) and overall survival (OS) than those without EAOC (5-year RFS: 91.4% vs. 73.0%, respectively, and 5-year OS: 97.5% vs. 89.9%). However, EAOC was not identified as a significant prognostic predictor in multivariate analysis. The potential risk factors determined to be associated with EAOC included the pretreatment CA-125 level, FIGO stage, lymphovascular space invasion (LVSI), and menopausal status (P<0.001, P=0.0031, P=0.020, and P=0.038, respectively).ConclusionsEndometriosis was not independently associated with the prognosis of the OCCC patients, even when the tumor was confined to stage I. However, the intrinsic relationship between endometriosis and OCCC warrants further investigation.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Antineoplastic Combined Chemotherapy Protocols Endometriosis Hysterectomy Ovarian Neoplasms Ovariectomy Salpingectomy Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Aged Antineoplastic Combined Chemotherapy Protocols CA-125 Antigen CA-125 Antigen Carboplatin Carboplatin Cisplatin Cisplatin Cyclophosphamide Cyclophosphamide

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (10)

Source provenance

europepmc
last seen: 2026-08-10T06:11:17.106188+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:49.724109+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK