Endometriosis-associated ovarian cancer is not a distinct clinical entity among young patients: A 12-year cohort study

Yan Cai, Jie Yin, Ying Jin, Yan Li, Ming Wu, Jiaxin Yang, Huifang Huang, Jinhua Leng, Lingya Pan
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2019 · vol. 46(5) , pp. 876–882 · doi:10.1016/j.ejso.2019.11.517 · PMID:31837932 · W2990162515
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This 12-year cohort study found that endometriosis is not independently associated with the prognosis of ovarian endometrioid and clear cell carcinomas in patients aged 40 or younger.

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Abstract

OBJECTIVES: To investigate the clinicopathological features and prognostic value of endometriosis in young patients with ovarian endometrioid carcinoma (OEC) and ovarian clear cell carcinoma (OCCC). METHODS: The medical files and clinical follow-up data of patients aged 40 years or younger with OEC or OCCC between January 2006 and December 2017 who had undergone complete surgical staging followed by systemic chemotherapy were retrospectively reviewed. RESULTS: A total of 94 women were included in this study. Univariate analysis revealed that the progression-free survival (PFS) and overall survival (OS) rates of patients with endometriosis-associated ovarian carcinoma (EAOC) did not improve compared with those of patients without EAOC (5-year PFS: 80.0% vs. 75.9% and 5-year OS: 85.0% vs. 86.0%, respectively). Multivariate analyses confirmed that FIGO stage (II-IV), cytology-positive ascites or peritoneal washes and residual disease > 1 cm were independent predictors of PFS and that residual disease > 1 cm was the only predictor of OS. CONCLUSIONS: Endometriosis is not independently associated with the prognosis of OEC and OCCC among young patients. The intrinsic relationship between endometriosis and ovarian cancer warrants further investigation.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_pain

MeSH descriptors

Adenocarcinoma, Clear Cell Antineoplastic Combined Chemotherapy Protocols Carcinoma, Endometrioid Carcinoma, Ovarian Epithelial Cytoreduction Surgical Procedures Endometriosis Ovarian Diseases Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adolescent Adult Antineoplastic Combined Chemotherapy Protocols CA-125 Antigen CA-125 Antigen Carboplatin Carboplatin Carcinoma, Endometrioid

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