The effect of concurrent endometriosis on the prognosis of women with ovarian clear cell or endometrioid carcinoma

U Chul Ju, Woo Dae Kang, Seok Mo Kim
International Journal of Gynecology & Obstetrics · 2019 · vol. 146(2) , pp. 177–183 · doi:10.1002/ijgo.12861 · PMID:31081117 · W2945470378
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Ovarian clear cell and endometrioid carcinomas were diagnosed at an earlier stage in women with concurrent endometriosis, but its presence did not impact survival outcomes.

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Abstract

OBJECTIVES: To evaluate features of ovarian clear cell carcinoma (CCC) and endometrioid carcinoma (EC) by presence of endometriosis among women with endometriosis-associated ovarian cancer (EAOC). METHODS: A retrospective review of the medical records of 578 women diagnosed and treated for ovarian cancer at a university hospital in Korea between July 2004 and December 2016. Clinical and prognostic features of ovarian CCC and EC were compared between women with endometriosis and those without. RESULTS: Ovarian CCC and EC were diagnosed at an earlier FIGO stage for women with endometriosis than for those without (P=0.033). The 5-year disease-free survival (DFS) and overall survival (OS) were 77.6% vs 65.0% (P=0.038) and 80.3% vs 70.9% (P=0.048), respectively. In univariate analysis, advanced stage, higher grade, bilateral tumors, lymph node metastasis, residual tumor greater than 1 cm, and non-concurrent endometriosis were related to shorter DFS and OS; however, residual tumor greater than 1 cm was the only independent predictor in multivariate analysis (DFS: hazard ratio (HR), 9.83; 95% confidence interval (CI), 4.84-19.93; OS: HR, 5.07; 95% CI, 2.33-11.03). No factors affected survival after stratification by stage. CONCLUSION: No association was found between the presence of endometriosis and the prognosis of ovarian CCC or EC.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Carcinoma, Ovarian Epithelial Endometriosis Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Case-Control Studies Disease-Free Survival Endometriosis Endometriosis Female Humans Lymphatic Metastasis Middle Aged

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