Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma

Park JY, Jeong-Yeol Park, Jeong‐Yeol Park, Dae‐Yeon Kim, Kim DY, Dae-Yeon Kim, Suh DS, Dae‐Shik Suh, Dae-Shik Suh, Kim JH, Jong-Hyeok Kim, Yong‐Man Kim, Yong-Man Kim, Kim YM, Young‐Tak Kim, Kim YT, Young-Tak Kim, Joo‐Hyun Nam, Nam JH, Joo-Hyun Nam
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2017 · vol. 28(1) , pp. 11–18 · doi:10.1097/igc.0000000000001136 · PMID:28930811 · W2756126606
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This study investigated the impact of ovarian endometriosis on the prognosis of ovarian clear cell carcinoma, analyzing survival outcomes in patients with and without co-existing endometriosis.

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Abstract

IntroductionThe aim of this study was to evaluate the significance of ovarian endometriosis on the prognosis of ovarian clear cell carcinoma (OCCC).MethodsPatients with OCCC were divided into 2 groups according to the presence of ovarian endometriosis: group 1, no coexisting ovarian endometriosis; group 2, clear cell carcinoma arising from ovarian endometriosis or the presence of ovarian endometriosis elsewhere in the ovary. Clinicopathologic characteristics, disease-free survival (DFS), and overall survival (OS) were compared between the 2 groups.ResultsOf 155 patients with OCCC, 77 were categorized into group 1 and 78 into group 2. Group 2 patients were younger than group 1 (median age, 48 vs 51 years; P = 0.005) and had higher incidence of early-stage disease (stage I, 77% vs 58%; P = 0.001) and lower incidence of lymph node metastasis (4% vs 17%; P = 0.008). Group 2 patients were observed to have a significantly higher 5-year DFS (P < 0.001) and OS (P = 0.001) compared with group 1. In stage I disease, group 2 had a significantly higher 5-year DFS (P = 0.004) and OS (P = 0.016) than did group 1. In the multivariate analysis, coexisting endometriosis and advanced International Federation of Obstetrics and Gynecology stage were significant factors for both DFS and OS rates.ConclusionsOvarian clear cell carcinoma with endometriosis was found more frequently in younger women and had a higher incidence of early-stage disease and a lower incidence of lymph node metastasis compared with OCCC without endometriosis. Ovarian endometriosis was associated with improved prognostic factors and a better DFS and OS even in stage I disease. Ovarian endometriosis was an independent prognostic factor for OCCC.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Ovarian Diseases Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Aged Endometriosis Endometriosis Endometriosis Female Humans Middle Aged Ovarian Diseases Ovarian Diseases Ovarian Diseases Ovarian Neoplasms Ovarian Neoplasms

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