Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis

Konstantinos Sapalidis, Nikolaos Machairiotis, Paul Zarogoulidis, Sofia Vasilakaki, Chrysanthi Sardeli, Georgios Koimtzis, George Koimtzis, Efstathios Pavlidis, Athanasios Katsaounis, Dimitrios Giannakidis, Nikolaos Michalopoulos, Stylianos Mantalobas, Vyron Alexandrou, Charilaos Koulouris, Aikaterini Amaniti, Ισαάκ Κεσίσογλου, Isaak Kesisoglou
International journal of molecular sciences · 2019 · vol. 20(8) , pp. 1842 · doi:10.3390/ijms20081842 · PMID:31013963 · PMC6515388 · W2940331387
review OA: gold CC0 ⤵ 13 in-corpus citations
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This review correlates recent clinical and experimental data, highlighting gene interactions and mutations in hub genes as pivotal in the malignant transformation of endometriosis.

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Abstract

The genetic and epigenetic factors that contribute to the malignant transformation of endometriosis are still under investigation. The objective of the present study was to investigate the genetic link between endometriosis and cancer by examining and correlating the latest clinical observations with biological experimental data. We collected updated evidence about the genetic relationship between endometriosis and cancers by conducting a comprehensive search of PubMed and Scopus databases, focusing on the papers published between January 2018 and January 2019. New insights into the mechanism of the malignant transformation of endometriosis have been published recently. The use of state-of-the-art techniques and methods, such as the genome-wide association study analysis and the weighted gene co-expression analysis, have significantly altered our understanding of the association between endometriosis and endometriosis-associated cancer development. Interestingly, the interactions formed between genes seem to play a pivotal role in the phenotypic expression of mutations. Therefore, the effect of single nucleotide polymorphisms and the function of the expression quantitative trait loci on genes' expression have been the subject of many recent works. In addition, it has been discovered that genes, the mutations of which have been related to the development of endometriosis, play a role as hub genes. This may lead to new areas of research for understanding the mechanism of malignant transformation of the disease. Significant steps forward have been made towards the identification of factors that control the malignant transformation of endometriosis. Still, due to rarity of the event, a better-organized scheme for sampling on a global level should be adopted.

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Condition tags

endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometriosis Ovarian Neoplasms Biomarkers Biomarkers Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Female Humans Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Polymorphism, Single Nucleotide Quantitative Trait Loci

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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