Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis

Jiaqi Lu, Xiang Tao, Jiayi Zhou, Yingying Lu, Zehua Wang, Haiou Liu, Congjian Xu
Oncotarget · 2016 · vol. 8(4) , pp. 5843–5852 · doi:10.18632/oncotarget.13967 · PMID:27992377 · PMC5351594 · W2561149705
article OA: gold CC0 ⤵ 12 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that ovarian cancer arising in endometriosis, often clear cell histology and early stage, is an independent predictor of improved progression-free and overall survival.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective study evaluated 196 patients with ovarian carcinoma, comparing tumors pathologically identified as arising in endometriosis (n=58, reconfirmed by H&E and CD10 immunohistochemistry of stromal cells) versus ovarian cancer without concomitant endometriosis (n=138), and assessed clinicopathologic features and survival outcomes using Kaplan-Meier/log-rank and Cox regression. Patients with endometriosis-associated ovarian cancer showed more early-stage diagnoses (FIGO I–II) and lower frequencies of intraperitoneal metastasis, high CA125, and preoperative ascites, and were associated with better overall survival and late recurrence in overall and early-stage (FIGO I–II) subgroup analyses; endometriosis was also an independent protective predictor for PFS and OS in multivariate models. A key limitation explicitly noted in the prompt context is that endometriosis-associated ovarian cancer criteria are heterogeneous and prior studies have conflicting results, which the authors attempt to address through standardized pathological identification, but the work remains observational and based on this single cohort. This paper is centrally about endometriosis — it specifically characterizes ovarian carcinomas arising in endometriosis using CD10/H&E pathological reconfirmation and evaluates the prognostic impact of endometriosis on PFS and OS.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

// Jiaqi Lu 1,* , Xiang Tao 3,* , Jiayi Zhou 2 , Yingying Lu 1 , Zehua Wang 2 , Haiou Liu 2 and Congjian Xu 1,2 1 Department of Gynaecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China 2 Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China 3 Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China * These authors have contributed equally to this work Correspondence to: Haiou Liu, email: // Congjian Xu, email: // Keywords : ovarian cancer, endometriosis, overall survival, progression-free survival, prognostic marker Received : May 30, 2016 Accepted : December 12, 2016 Published : December 15, 2016 Abstract Background: Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is to assess the association between endometriosis and the prognosis in patients with ovarian cancer. Results: Ovarian cancer arising in endometriosis tended to be presented as clear cell histology, early stage, less intraperitoneal metastasis and ascites, and lower CA125 level compared with those without endometriosis. Multivariate Cox regression analysis identified endometriosis as an independent prognostic factor for progression free survival ( P = 0.002) and overall survival ( P = 0.009) in all patients and especially for early stage. A nomogram integrating endometriosis, FIGO stage and CA125 was established to predict progression free survival and overall survival. Materials and methods: This study retrospectively enrolled 196 ovarian cancers arising or not in endometriosis judged by adjunctive use of CD10 immunohistochemistry in conjunction with H&E staining specimens. Clinicopathologic variables, progression-free survival (PFS) and overall survival (OS) were recorded. Kaplan-Meier analysis was performed to compare survival curves. Cox regression models were used to analyze the effect of endometriosis on PFS and OS. A prognostic nomogram was constructed based on the independent prognostic factors identified by multivariate analysis. Conclusions: Endometriosis is an independent predictor of prognosis in ovarian cancer patients.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Nomograms Ovarian Neoplasms CA-125 Antigen CA-125 Antigen Disease-Free Survival Endometriosis Endometriosis Female Humans Membrane Proteins Membrane Proteins Middle Aged Neoplasm Staging Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Prognosis Proportional Hazards Models Retrospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (12)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:43.714878+00:00
License: CC0 · commercial use OK