Clinical Outcomes of Patients with High-Grade Ovarian Carcinoma Arising in Endometriosis Compared to Ovarian High-Grade Serous Carcinoma

Purpose To compare the prognoses of women with high-grade ovarian carcinoma arising in endometriosis (OCAE) to those of women with ovarian high-grade serous carcinoma (HGSC)

This multicenter, retrospective, case–control study included patients with OCAE at two gynecologic oncology centers in Turkey between January 2006 and December 2016. Of a total of 202 women with a diagnosis of OCAE, 70 women with high-grade OCAE were included. Each case high-grade OCAE was attributed to two women with ovarian HGSC. Survival analysis was performed using the Kaplan–Meier method.

Eleven patients with high-grade OCAE had recurrent disease (15.7%) when compared to 47 patients (33.6%) with HGSC (p = 0.008). The 5-year disease-free survival (DFS) rate of the patients having high-grade OCAE was significantly higher than the women with HGSC (78.3% vs. 56.2%; p = 0.007, respectively). According to the 5-year overall survival (OS) rates, there was no significant difference between high-grade OCAE and HGSC (79.5% vs. 70.1%; p = 0.210, respectively).

Although this retrospective study demonstrated a significant decrease in recurrence rate and an increase in the 5-year DFS rate in patients with high-grade OCAE, OS rates of the patients with HGSC and high-grade OCAE seem to be similar. Similar content being viewed by others

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ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease. Ann Oncol. 2019;30(5):672–705. https://doi.org/10.1093/annonc/mdz062. Funding This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. Author information Authors and Affiliations Contributions I. Y., H. C., M. M. M., A. A. performed surgical and medical practices; I. Y., M. M. M., A. A. provided the concept; H. C., M. M. M., A. A. designed the study; I. Y., H. S., M. E. S. were involved in data collection or processing; A. N. H., E. A. S., H. C., M. M. M. contributed to analysis or interpretation; M. E. S., A. N. H., E. A. S performed literature search; I. Y., M. M. M. wrote the article. Corresponding author Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. Ethics Approval This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Institutional review board approved retrospective analysis of the Cancer Registry database (Approval date: Feb 12th 2018 Approval number: 23). Informed consent Informed consent was obtained from all individual participants included in the study. Consent to publish Patients signed informed consent regarding publishing their data. Availability of data All data and materials support their published claims and comply with field standards. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions About this article Cite this article Yalcin, I., Sahin, H., Sari, M.E. et al. Clinical Outcomes of Patients with High-Grade Ovarian Carcinoma Arising in Endometriosis Compared to Ovarian High-Grade Serous Carcinoma. Indian J Gynecol Oncolog 19, 58 (2021). https://doi.org/10.1007/s40944-021-00559-z Received: Revised: Accepted: Published: Version of record: DOI: https://doi.org/10.1007/s40944-021-00559-z