Malignant degeneration of rectal endometriosis

José Andrés García-Marín, Enrique Pellicer‐Franco, Enrique Manuel Pellicer-Franco, Víctor Soria‐Aledo, Victoriano Soria-Aledo, Mónica Mengual-Ballester, Graciela Valero-Navarro, José Luís Aguayo-Albasini, José Luis Aguayo-Albasini
Revista espanola de enfermedades digestivas · 2015 · vol. 107(12) , pp. 761–3 · doi:10.17235/reed.2015.3648/2014 · PMID:26671590 · W2462528561
article OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case report describes a rectal lesion initially diagnosed as primary rectal malignancy that was ultimately identified as adenocarcinoma arising from endometrial tissue within the colonic wall.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This 2015 case report describes a patient with a rectal lesion initially managed as a primary rectal malignancy, whose histopathology ultimately showed adenocarcinoma arising from endometrial tissue within the colonic wall. The authors discuss that while bowel endometriosis is uncommon, malignant transformation of endometriotic lesions is estimated at 0.3%–1%, and that diagnosis of intestinal endometriosis is confirmed by pathological study of specimens, with exploratory laparotomy cited as the gold standard. The report notes that although adjuvant radiotherapy and chemotherapy are used for some patients, they have not proven effective. This paper is centrally about endometriosis — specifically malignant degeneration of rectal endometriosis presenting as an adenocarcinoma.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

BACKGROUND: Endometriosis is a relatively common disease among women with child-bearing potential, and rare before puberty or following menopause. It consists of the presence of hormone-responsive endometrium outside the endometrial cavity. CASE REPORT: We report the case of a patient with a rectal lesion, initially approached as a primary rectal malignancy, where histopathology eventually revealed an adenocarcinoma arising from endometrial tissue in the colonic wall. DISCUSSION: Endometriosis has an estimated rated of 10-20%. Sites may be split up into two larger categories - gonadal and extragonadal. The frequency of extragonadal endometriosis in the bowel is estimated to involve 3%-37% of women with pelvic endometriosis, and most lesions are found in the sigmoid colon and rectum. The malignant transformation of endometriotic lesions is estimated between 0.3% and 1% of cases. The gold standard in the diagnosis of intestinal endometriosis is exploratory laparotomy and the pathological study of specimens. Adjuvant radiotherapy and chemotherapy, although used for some patients, have not proven effective.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Cell Transformation, Neoplastic Colonic Diseases Endometriosis Precancerous Conditions Rectal Neoplasms Adenocarcinoma Colonic Diseases Endometriosis Female Humans Middle Aged Precancerous Conditions Rectal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (11)

Source provenance

europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:33.600579+00:00
License: CC0 · commercial use OK