Clinical evaluation of CA-125 concentrations as a prognostic factor for pregnancy in infertile women with surgically treated endometriosis
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This study evaluated CA-125 concentrations as a prognostic factor for pregnancy in infertile women who underwent surgical treatment for endometriosis.
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Abstract
OBJECTIVE: To extend and confirm earlier observations that serial CA-125 determinations appear to have prognostic value in some infertile women with surgically treated endometriosis using a new automated enzyme immunoassay.
DESIGN: A prospective consecutive case series.
SETTING: A university-based tertiary practice.
PATIENTS: Of 342 women having a laparoscopy for infertility, 123 (36%) had endometriosis. Fifty-six of 123 (45%) infertile women with endometriosis had preoperative CA-125 values > or = 16 U/mL and were followed for 12 months with serial CA-125 determinations.
MAIN OUTCOME MEASURE: Proportion of women achieving a pregnancy within 12 months from surgery.
RESULTS: Mean preoperative CA-125 concentrations were not statistically different for women conceiving, but mean postoperative CA-125 values were significantly lower for women achieving a pregnancy. Univariate analyses indicated that preoperative CA-125 values between 16-25 U/mL and postoperative CA-125 values < 16 U/mL were associated with significantly higher pregnancy rates. Multivariate analyses of 10 covariables indicated only postoperative CA-125 concentrations to be associated with pregnancy even after controlling for all covariables.
CONCLUSION: Using a newly developed assay for CA-125, the study confirms and extends earlier observation that CA-125 concentrations have prognostic value for pregnancy in infertile women with surgically treated endometriosis. The findings provide additional support for the clinical use of CA-125 concentrations in selected women with endometriosis.
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- Relationship between the serum cancer antigen 125 level and the weight of surgically enucleated adenomyosis 2022
- MicroRNA let-7: A promising non-invasive biomarker for diagnosing and treating external genital endometriosis 2021
- Correlation of CA-125 with different stages of endometriosis 2018
- Identifying biomarkers for non-invasive diagnosis of endometriosis 2016
- Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis 2016
- Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis 2016
- Serum markers for the noninvasive diagnosis of endometriosis 2015
- Problems with the diagnosis of endometriosis 2015
- Correlation between ovarian chocolate cyst and serum carbohydrate antigen 125 level and the effect of ultrasound-guided interventional sclerotherapy on serum carbohydrate antigen 125 level 2014
- Biomarkers of peritoneal fluid in endometriosis identified by surface-enhanced laser desorption/ionization time-of-flight 2014
- ACUPUNCTURE IMPROVES THE EFFECTS OF CHINESE HERBAL MEDICINE IN TREATING ENDOMETRIOSIS MODEL RATS 2013
- Do inflammatory factors play a significant role in etiopathogenesis of endometrial cysts? Part 1 2013
- Endometriosis: Disease Classification and Behavior 2011
- Avaliação do CA-125 e do CD-23 solúvel em pacientes com endometriose pélvica 2011
- "Wpyw preparatu RESAN na odpowied ź immunologiczn ą typu Th 1 i Th2 w endometriozie- badanie do świadczalne na modelu zwierz ęcym" 2011
- Pathophysiology of Infertility in Endometriosis 2011
- Diagnosis of Endometriosis: Biomarkers 2011
- Avaliação do CA-125 e do CD-23 solúvel em pacientes com endometriose pélvica 2010
- Useful Biomarkers for the Diagnosis of Endometriosis 2010
- Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values 2009
- The Correlation between Serum and Peritoneal Fluid CA125 Level in Women with Pelvic Endometriosis 2009
- Biomarkers of endometriosis 2008
- [Management of endometriosis: clinical and biological assessment] 2007
- Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis 2006
- Contribution to the physiopathology, symptomatology and treatment of deep infiltrating endometriosis 2004
- Marcadores tumorales en la endometriosis: relación con la gravedad de la enfermedad 2004
- Implantation defects in infertile women with endometriosis 2002
- Prediction of pregnancy in infertile women with endometriosis 2002
- Deeply infiltrating endometriosis: implications, diagnosis, and management 2001
- An update on the classification of endometriosis 1999
- Correlation of basal menses CA-125 levels and 6 month pregnancy rates in women undergoing treatments for infertility without assisted reproductive methods 1997
- Classification of endometriosis 1997
- Revised endometriosis classification: 1996 1997
- Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis 1997
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996 1997
- Revised endometriosis classification: 1996 1997
- Evaluation of serum CA 125 concentrations as predictors of pregnancy with human in vitro fertilization 1996
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