Biomarkers of peritoneal fluid in endometriosis identified by surface-enhanced laser desorption/ionization time-of-flight

L Wang, X Y Ding, Xiaoyan Ding, Jiachuan Yu, J K Yu, S Z Zhang, W Zheng, Wei Zheng
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(1) , pp. 72–74 · doi:10.12891/ceog16342014 · PMID:24707688 · W10639873
article OA: bronze CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry identified four potential protein biomarkers in peritoneal fluid that could aid in diagnosing endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The study aimed to characterize proteomic patterns in peritoneal fluid from endometriosis patients, identify potential protein biomarkers, and construct diagnostic models using surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF-MS). Peritoneal fluid from 14 women with endometriosis and 16 without endometriosis was analyzed with SELDI-TOF-MS protein chip array technology. Four potential biomarkers at m/z 4428, 6891, 13766, and 6427 were reported as discriminating features, and the authors concluded the approach has potential for finding improved endometriosis biomarkers, though the small sample size was a key limitation implied by the study design. This paper is centrally about endometriosis — it uses peritoneal fluid proteomic profiling to identify diagnostic biomarker peaks in endometriosis.

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Abstract

OBJECTIVES: This work aims to detect the peritoneal fluid proteomic patterns in endometriosis patients, build diagnostic models, and evaluate its clinical significance. STUDY DESIGN: The authors used SELDI-TOF-MS protein chip array technology to detect biomarkers of peritoneal fluid in endometriosis patients. Fourteen endometriosis patients and 16 persons without endometriosis as control group were tested. RESULTS: Four potential biomarkers (4428m/z, 6891m/z, 13766m/z, and 6427m/z) were found. CONCLUSIONS: This method showed great potential in screening better biomarkers for endometriosis.
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Abstract

Objectives: This work aims to detect the peritoneal fluid proteomic patterns in endometriosis patients, build diagnostic models, and evaluate its clinical significance. Study Design: The authors used SELDI-TOF-MS protein chip array technology to detect biomarkers of peritoneal fluid in endometriosis patients. Fourteen endometriosis patients and 16 persons without endometriosis as control group were tested. Results: Four potential biomarkers (4428m/z, 6891m/z, 13766m/z, and 6427m/z) were found. Conclusions: This method showed great potential in screening better biomarkers for endometriosis.

Keywords

- Endometriosis - Peritoneal fluid - Surface-enhanced laser desorption/ionization time-of-flight - Biomarkers - adenomyosis

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Biomarkers Endometriosis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Adult Ascitic Fluid Biomarkers Endometriosis Endometriosis Female Humans Protein Array Analysis Protein Array Analysis Young Adult

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