Effect of early endometriosis on ovarian reserve and reproductive outcome

Kotaro Kitaya
Frontiers in bioscience (Scholar edition) · 2015 · vol. 7(1) , pp. 40–45 · doi:10.2741/s423 · PMID:25961685 · W1251623471
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Early pelvic endometriosis negatively affects ovarian reserve and luteal function in infertile women undergoing IVF but not their final reproductive outcome.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

The paper reviews evidence on whether early pelvic endometriosis (minimal or mild disease) affects ovarian reserve and reproductive outcomes, focusing on markers such as anti-Mullerian hormone and antral follicular count as well as fertilization and luteal function in studies of infertile women undergoing IVF. It synthesizes prior findings suggesting that while advanced endometriosis is consistently linked to reduced fecundity, the effects of early endometriosis on human reproduction are less clear and may vary by outcome measure. A key limitation noted is the remaining uncertainty in the human evidence base regarding early disease specifically. This paper is centrally about endometriosis — it reviews how early (minimal/mild) endometriosis may influence ovarian reserve and reproductive outcomes in the context of IVF.

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Abstract

Accumulating evidence suggests that advanced (moderate/severe) endometriosis negatively affects female fecundity, whereas the influence of early (minimal/mild) endometriosis on human reproduction remains unclear. Recent studies showed that the presence of the early pelvic endometriosis lesions deteriorates the ovarian reserve, luteal function, and fertilization rate in infertile women undergoing in vitro fertilization-embryo transfer treatment, but not their final reproductive outcome. Meanwhile, laparoscopic resection of early endometriosis lesions may be a promising therapeutic option to improve the fecundity of the affected subfertile women. Insufficient evidence on the relationship between early endometriosis, ovarian reserve, and reproductive outcome warrants further investigations.
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Abstract

Accumulating evidence suggests that advanced (moderate/severe) endometriosis negatively affects female fecundity, whereas the influence of early (minimal/mild) endometriosis on human reproduction remains unclear. Recent studies showed that the presence of the early pelvic endometriosis lesions deteriorates the ovarian reserve, luteal function, and fertilization rate in infertile women undergoing

Keywords

- Anti-Mullerian hormone - Antral follicular count - Early endometriosis - Ovarian reserve - Reproductive outcome - Review

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Reserve Animals Corpus Luteum Corpus Luteum Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Ovarian Reserve Pregnancy Pregnancy Outcome

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