Endometriosis and Angiogenic Factors

P. G., Pedro J Grases G, M. Ruggiero, María Ruggiero, Francesca Papini, F. Papini, G. Simi, Vito Cela, V. Cela, Alvarez Zamora R, A. R.
Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/29121 · W1486805211
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Endometriotic implants require neovascularization for establishment and maintenance, driven by interactions between ectopic endometrium and peritoneal tissue.

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This chapter reviews the role of angiogenic factors in the pathophysiology of endometriosis, highlighting how abnormal blood vessel formation supports the growth and survival of ectopic endometrial tissue. It examines specific molecules such as vascular endothelial growth factor (VEGF) and their influence on lesion establishment, inflammation, and pain associated with the disease. The text synthesizes existing literature to demonstrate that angiogenesis is a critical process in endometriotic implantation and progression. This paper is centrally about endometriosis — specifically examining the mechanistic link between angiogenic factors and disease pathology.

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Abstract

The development of new blood vessels represents a crucial step during the establishment of endometriosis because endometriotic implants require neovascularization to guarantee oxygen and essential nutrient supply (Groothuis et al., 2005; McLaren, 2000). The interaction between the ectopic endometrium and the peritoneal tissue is a prerequisite for the induction of angiogenesis and the maintenance of endometriosis
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Open access Submitted: 04 March 2011 Published: 09 May 2012 DOI: 10.5772/29121 From the Edited Volume Edited by Koel Chaudhury and Baidyanath Chakravarty Submitted: 04 March 2011 Published: 09 May 2012 © 2012 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Discover 2026 Nobel Laureate Francis Halzen’s chapter on IntechOpen >

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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