Angiogenesis and its control in the female reproductive system
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OA: bronze
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⤵ 17 in-corpus citations
AI-generated summary
The female reproductive system's cyclical angiogenesis can be manipulated with angiogenic and anti-angiogenic compounds to influence ovarian and endometrial function and treat related pathologies.
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Abstract
The rapid, controlled and cyclical nature of angiogenesis in the female reproductive tract suggests that interference with this process should provide a novel approach to manipulation of reproductive function. Many factors involved in the regulation of angiogenesis have been identified, and the possibility of stimulating or inhibiting these paracrine control mechanisms is being addressed using current advances in the development of angiogenic and anti-angiogenic compounds. Studies with animal models indicate that the normal processes of folliculogenesis, ovulation and corpus luteum function in the ovary, and the control of menstruation and implantation in the endometrium could be profoundly influenced by manipulation of angiogenesis. Novel therapeutic agents targeted to the angiogenic pathway may also have a wide range of applications in pathological processes in the reproductive tract such as cancer, endometriosis, fibroid growth, and ovarian hyperstimulation syndrome.
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Cited by (17)
- Involvement of NADPH oxidase and NF-κB activation in CXCL1 induction by vascular endothelial growth factor in human endometrial epithelial cells of patients with adenomyosis 2016
- Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system 2014
- Role of pigment epithelium-derived factor in the reproductive system 2014
- Endometriosis and Angiogenic Factors 2012
- Prolactin in Ovarian Follicular Fluid Stimulates Endothelial Cell Proliferation 2009
- Estrogen and selective estrogen receptor modulators regulate vascular endothelial growth factor and soluble vascular endothelial growth factor receptor 1 in human endometrial stromal cells 2009
- Endometriosis 2008
- Angiogenesis and antiangiogenic therapy in endometriosis 2007
- Emerging drugs in endometriosis 2006
- Endostatin inhibits the growth of endometriotic lesions but does not affect fertility 2005
- Vascular Endothelial Growth Factor Trap Suppresses Ovarian Function at All Stages of the Luteal Phase in the Macaque 2005
- Increased concentration of vascular endothelial growth factor in the follicular fluid of patients with endometriosis does not affect the outcome of in vitro fertilization–embryo transfer 2003
- An improved mouse model for endometriosis allows noninvasive assessment of lesion implantation and development 2003
- Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis 2003
- Experimental Endometriosis 2002
- Angiogenesis in the female reproductive organs: pathological implications 2002
- Angiogenic activity and IL‐8 concentrations in peritoneal fluid and sera in endometriosis 2002
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:13:24.901228+00:00
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