Angiogenesis and its control in the female reproductive system

Fraser HM, Hamish M. Fraser, H. M. Fraser, Lunn SF, S. F. Lunn
British medical bulletin · 2000 · vol. 56(3) , pp. 787–797 · doi:10.1258/0007142001903364 · PMID:11255562 · W2110373505
Review OA: bronze CC0 ⤵ 17 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

The female reproductive system's cyclical angiogenesis can be manipulated with angiogenic and anti-angiogenic compounds to influence ovarian and endometrial function and treat related pathologies.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The rapid, controlled and cyclical nature of angiogenesis in the female reproductive tract suggests that interference with this process should provide a novel approach to manipulation of reproductive function. Many factors involved in the regulation of angiogenesis have been identified, and the possibility of stimulating or inhibiting these paracrine control mechanisms is being addressed using current advances in the development of angiogenic and anti-angiogenic compounds. Studies with animal models indicate that the normal processes of folliculogenesis, ovulation and corpus luteum function in the ovary, and the control of menstruation and implantation in the endometrium could be profoundly influenced by manipulation of angiogenesis. Novel therapeutic agents targeted to the angiogenic pathway may also have a wide range of applications in pathological processes in the reproductive tract such as cancer, endometriosis, fibroid growth, and ovarian hyperstimulation syndrome.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inhibitors Contraception Ovarian Follicle Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Animals Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Callithrix Callithrix Contraception Contraception Contraception Endothelial Growth Factors Endothelial Growth Factors Endothelial Growth Factors Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (17)

Source provenance

europepmc
last seen: 2026-10-13T06:10:10.580696+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T20:59:53.382863+00:00
License: CC0 · commercial use OK