The Peritoneal Fluid Levels of Interleukin‐12 in Women with Endometriosis

H B Zeyneloglu, Hulusi Bülent Zeyneloğlu, L M Senturk, Levent M. Şentürk, Seli E, Emre Seli, E Seli, O M Bahtiyar, Mert Ozan Bahtiyar, D L Olive, David L. Olive, Olive DL, A Arici, Aydın Arıcı, Arici A
American journal of reproductive immunology (New York, N.Y. : 1989) · 1998 · vol. 39(2) , pp. 152–156 · doi:10.1111/j.1600-0897.1998.tb00347.x · PMID:9506213 · W2084146249
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Peritoneal fluid levels of interleukin-12 were measured in women with and without endometriosis, revealing low and statistically similar concentrations in both groups.

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Abstract

PROBLEM: Interleukin-12 (IL-12) is produced mainly by monocytes/macrophages, and it induces proliferation and cytotoxicity of T-cells and natural killer cells. In women with endometriosis, natural killer cell activity in the peritoneal fluid is significantly decreased. We aimed to measure the peritoneal fluid level of IL-12 in endometriosis. METHOD OF STUDY: We measured IL-12 levels in peritoneal fluid samples from women with or without endometriosis and in supernatants from endometrial stromal, ovarian stromal, and mesothelial cell cultures, using a high-sensitivity enzyme-linked immunosorbent assay. RESULTS: The median concentration of IL-12 in the peritoneal fluid of women with endometriosis was 1.1 pg/ml (range, 0.2-5.5) and was 1.6 pg/ml (range, 0.4-2.8) in women without endometriosis, not a statistically significant difference. IL-12 was not detected in the supernatants of endometrial stromal, ovarian stromal, and mesothelial cell cultures. CONCLUSION: Concentrations of IL-12 in the peritoneal fluid of women with or without endometriosis are low, but they are detectable and are not affected significantly by the presence of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-12 Adult Ascitic Fluid Case-Control Studies Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Epithelium Epithelium Female Humans Interleukin-12 Ovary Ovary

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