Recombinant Interleukin‐2 Corrects In Vitro the Immunological Defect of Endometriosis

Giovanni Melioli, G Melioli, Melioli G, SEMINO C, C Semino, Claudia Semino, A. Semino, Semino A, Venturini PL, Pier Luigi Venturini, P. L. Venturini, Ragni N, N. Ragni, Nicola Ragni
American journal of reproductive immunology (New York, N.Y. : 1989) · 1993 · vol. 30(4) , pp. 218–227 · doi:10.1111/j.1600-0897.1993.tb00623.x · PMID:7907480 · W2092295906
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Recombinant interleukin-2 restored the diminished cytotoxic activity of T-cells against autologous endometrial cells in peripheral blood lymphocytes from endometriosis patients.

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Abstract

PROBLEM: It has been shown recently that women with endometriosis have several immunological defects. In particular, these patients have a defect in peripheral blood natural killer cell activity and have lost their capacity of recognizing and lysing autologous endometrial cells. METHOD: We evaluated the effect of recombinant interleukin-2 (rIL-2) on peripheral blood lymphocytes obtained from both healthy donors and endometriosis patients. The generation of a strong cytolytic activity against autologous endometrial cells was obtained from both normal donors and endometriosis patients. RESULTS: Interestingly, these cytolytic cells belong to the T-cell lineage and do not recognize both autologous keratinocytes and allogeneic endometrial cells, thus suggesting a mechanism of specific recognition of autologous cells. CONCLUSION: The capability of restoring cytolytic activity using rIL-2 suggests a new immunotherapeutic approach for the treatment of severe endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Interleukin-2 Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Autoimmunity CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD8 Antigens CD8 Antigens Cells, Cultured Cytotoxicity, Immunologic Endometriosis Endometriosis Female Humans Interleukin-2 In Vitro Techniques Isoantigens Keratinocytes

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