Recombinant interleukin-2 corrects in vitro the immunological defect of endometriosis

Giovanni Melioli, G Melioli, Melioli G, SEMINO C, C Semino, Claudia Semino, A. Semino, Semino A, Venturini PL, Pier Luigi Venturini, P. L. Venturini, Ragni N, N. Ragni, Nicola Ragni
American journal of reproductive immunology (New York, N.Y. : 1989) · 1993 · vol. 30(4) , pp. 218–227 · doi:10.1111/j.1600-0897.1993.tb00623.x · PMID:7907480 · W2092295906
Lab / animal OA: closed CC0 ⤵ 37 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

Recombinant interleukin-2 restored the diminished cytotoxic activity of T-cells against autologous endometrial cells in peripheral blood lymphocytes from endometriosis patients.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

PROBLEM: It has been shown recently that women with endometriosis have several immunological defects. In particular, these patients have a defect in peripheral blood natural killer cell activity and have lost their capacity of recognizing and lysing autologous endometrial cells. METHOD: We evaluated the effect of recombinant interleukin-2 (rIL-2) on peripheral blood lymphocytes obtained from both healthy donors and endometriosis patients. The generation of a strong cytolytic activity against autologous endometrial cells was obtained from both normal donors and endometriosis patients. RESULTS: Interestingly, these cytolytic cells belong to the T-cell lineage and do not recognize both autologous keratinocytes and allogeneic endometrial cells, thus suggesting a mechanism of specific recognition of autologous cells. CONCLUSION: The capability of restoring cytolytic activity using rIL-2 suggests a new immunotherapeutic approach for the treatment of severe endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Interleukin-2 Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Antigens, Differentiation, T-Lymphocyte Autoimmunity Autoimmunity CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD8 Antigens CD8 Antigens CD8 Antigens Cells, Cultured Cells, Cultured Cytotoxicity, Immunologic Cytotoxicity, Immunologic Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (38)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:59:07.256998+00:00
unpaywall
last seen: 2026-10-17T06:24:38.187582+00:00
License: CC0 · commercial use OK