Clear cell carcinoma arising from a uterus‐like mass

Baku Nakakita, Abiko K, Kaoru Abiko, Mikami Y, Yoshiki Mikami, Kido A, Aki Kido, Tsukasa Baba, Yumiko Yoshioka, Yoshioka Y, Ken Yamaguchi, Noriomi Matsumura, Konishi I, Ikuo Konishi
Pathology international · 2014 · vol. 64(11) , pp. 576–580 · doi:10.1111/pin.12218 · PMID:25359243 · W2164083813
article OA: closed CC0 ⤵ 9 in-corpus citations
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This case study details a 67-year-old woman who developed clear cell carcinoma within a rare retroperitoneal uterus-like mass, suggesting potential malignant transformation similar to endometriosis-related ovarian cancers.

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Abstract

A uterus-like mass is an extrauterine mass with a cavity lined by endometrial tissue and a smooth muscle layer resembling the uterine corpus. It is a rare condition of unknown histogenesis. Herein, we describe a case of clear cell carcinoma arising from a uterus-like mass located in the retroperitoneal space. The patient, a 67-year old nulliparous woman, had been followed with the diagnosis of an ovarian endometriotic cyst for 14 years until ultrasonography and magnetic resonance imaging (MRI) demonstrated an enlargement of the cystic mass with a thickened irregular wall. Suspicion of malignant transformation prompted us to excise the lesion. At laparotomy, the uterus and right ovary appeared normal, and a mass measuring 8 cm was identified in the retroperitoneal space without any connection to the uterus. Grossly, the removed mass was composed of a cyst filled with blackish-brownish fluid and a thick wall resembling uterine myometrium. Microscopically, endometrial tissue inside the cyst, which was diffusely lined by clear cell carcinoma, was identified. Although the histogenesis of a uterus-like mass remains unclear, this case indicates that malignant tumors may occur from a uterus-like mass through the pathway similar to the carcinogenesis of endometriosis-related ovarian neoplasms.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Cysts Endometriosis Uterine Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Aged Cysts Endometriosis Female Humans Muscle, Smooth Muscle, Smooth Ovary Ovary Uterine Neoplasms

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References (20)

Cited by (9)

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