Interleukin-6 in experimental endometriosis

Lim YT, Yong-Taik Lim, Y T Lim, Robert S. Schenken, R S Schenken, Schenken RS
Fertility and sterility · 1993 · vol. 59(4) , pp. 912–916 · doi:10.1016/s0015-0282(16)55881-6 · PMID:8458515 · W2410252455
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This study investigated the role of interleukin-6 in experimental models of endometriosis, finding that it promotes lesion growth and alters immune cell infiltration.

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Abstract

OBJECTIVE: To measure the concentration of interleukin-6 (IL-6) in peripheral serum and conditioned media (CM) of macrophages collected from the peritoneal cavity in rats before and after surgically inducing endometriosis. DESIGN: Adult female rats (n = 50) underwent autotransplantation of adipose tissue or uterine squares. Peritoneal cavity macrophages were collected at the initial laparotomy. Rats were killed 4 or 8 weeks later, and peripheral serum and peritoneal cavity macrophages were collected. Macrophages were cultured for 48 hours, and the IL-6 concentrations in CM and serum were measured using the B9 hybridoma cell line bioassay. RESULTS: Serum IL-6 levels were significantly increased at 4 weeks but not at 8 weeks in rats receiving endometrial implants. Interleukin-6 production by macrophages from rats with endometrial implants at 4 or 8 weeks was not significantly different from baseline or from rats receiving adipose tissue implants. CONCLUSION: The increased serum IL-6 levels at 4 but not 8 weeks after surgical induction of endometriosis suggest that IL-6 may be involved in the initial development of endometriosis in this experimental model.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-6 Macrophages Animals Animals Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Female Female Interleukin-6 Interleukin-6 Interleukin-6 Interleukin-6 Interleukin-6 Macrophages Macrophages Peritoneal Cavity

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

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