Comparison of cytokines in the peritoneal fluid and conditioned medium of adolescents and adults with and without endometriosis

Amelia P Bailey, Abby S Hill, Michael T Beste, Christi D Cook, Vishnudas Sarda, Marc R Laufer, Keith Isaacson, Keith B Isaacson, Linda G Griffith, Stacey A Missmer
American journal of reproductive immunology (New York, N.Y. : 1989) · 2020 · vol. 85(3) , pp. e13347 · doi:10.1111/aji.13347 · PMID:32946598 · W3087408155
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Abstract

PROBLEM: To compare inflammatory- and immune-associated peritoneal cytokines of adolescents and adults with and without endometriosis. METHODS OF STUDY: In a nested case-control study in multiple university-affiliated scientific centers, ten adolescents and thirteen adults with visually and histologically confirmed endometriosis (cases), thirteen adolescents with visually suspected endometriosis but indeterminate (seven patients) or negative (six patients) histology, and fifteen adults undergoing surgery for non-malignant gynecologic disease without endometriosis (controls) underwent laparoscopic aspiration of peritoneal fluid (PF), from which PF and conditioned medium (CM) cytokine levels were assayed. RESULTS: Compared to adults with endometriosis, MCP-3, IL-12p40, MIP-1β, and IL-15 were significantly higher among adolescents with endometriosis, while TNF-β and CTACK were lower among adolescents. These differences were similar comparing adolescents with endometriosis to adult controls except for MIP-1β, which was not statistically different. MIP-1β was, however, the only cytokine observed to differ between adult cases and controls. There were no significant differences in CM cytokines among the three groups. Results were similar when analyses were restricted to samples collected (a) during menstrual cycle days 1-10, (b) from patients unexposed to exogenous hormones, or (c) from all adolescents despite presence or absence of histologic endometriosis. CONCLUSION: Biologically relevant and statistically significant differences in six PF cytokines were observed and suggest a more pro-invasion cytokine profile among adolescents with endometriosis. Adolescents with endometriosis have unique peritoneal cytokine profiles and molecular behavior when compared to adults with and without endometriosis.

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mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Endometrium Inflammation Adolescent Adult Ascitic Fluid Case-Control Studies Cells, Cultured Culture Media, Conditioned Culture Media, Conditioned Cytokines Endometriosis Endometrium Female Humans Inflammation Menstrual Cycle Menstrual Cycle

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