Toll-Like Receptor 2 Expression as a New Hallmark of Advanced Endometriosis

Małgorzata Sobstyl, Paulina Niedźwiedzka‐Rystwej, Ewelina Grywalska, Izabela Korona‐Głowniak, Anna Sobstyl, Wiesława Bednarek, Jacek Roliński
Cells · 2020 · vol. 9(8) , pp. 1813 · doi:10.3390/cells9081813 · PMID:32751735 · W3046715106
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This study found that increased Toll-like receptor 2 expression on myeloid dendritic cells and B cells may serve as a diagnostic biomarker for advanced endometriosis, correlating with disease stage and associated complications.

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Abstract

Recent evidence suggests that immunological aspects play a pivotal role in this disorder. Toll-like receptor 2 (TLR2) is crucial in recognizing microbial infections and mediating innate immune response. The objective of our study was to rate with flow cytometry the levels of several subsets of dendritic cells, monocytes, and basic peripheral blood lymphocytes expressing TLR2, aiming at the determination of a possible correlation between the expression of TLR2 and the clinical outcomes of endometriosis in 40 patients and 40 age-matched healthy women. Our study showed the importance of TLR2 expression, mainly on myeloid dendritic cells (mDCs) and B cells in patients with endometriosis. Both mDCs BDCA1+CD19-TLR2+ and B lymphocytes CD19+TLR-2+ proved useful in the differentiation of affected individuals with stages 3–4 of the disease (area under the receiver operating characteristic curve /AUC/ = 0.96, p < 0.0001 for mDCs; AUC = 0.78, p = 0.0001 for B lymphocytes), and those presenting adhesion (AUC = 0.92, p < 0.0001 for mDCs; AUC = 0.82, p < 0.0001 for B lymphocytes) or infertility (AUC = 0.83, p < 0.0001 for mDCs; AUC = 0.73, p = 0.006 for B lymphocytes). Our findings suggest that the levels of TLR2-expressing cells, particularly mDCs and B lymphocytes, may be an effective biomarker of endometriosis, because the disease currently lacks clinically useful noninvasive biomarkers enabling early and cost-effective diagnosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Dendritic Cells Endometriosis Lymphocytes Monocytes Toll-Like Receptor 2 Adult Biomarkers Biomarkers Case-Control Studies Dendritic Cells Endometriosis Endometriosis Female Flow Cytometry Humans Immunity, Innate Lymphocytes Middle Aged Monocytes Prospective Studies

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