cGAS-STING pathway participates in endometriosis by up-regulating autophagy:Review.

sennan zhu, Qiu-yu Chen, Xinyi Du, XU Fengming, Zongwen Liang, Yu Zhao, qiong zhang
In: Authorea, Inc. · 2020 · doi:10.22541/au.160372880.07417845/v1 · W4213351056
preprint OA: gold CC0 ⤵ 1 in-corpus citation
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This review explores how the cGAS-STING pathway might contribute to endometriosis by up-regulating autophagy, suggesting potential therapeutic strategies.

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Abstract

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthetase (cGAS) and its downstream interferon gene stimulator (STING) act as important immune monitoring media have become a research hotspot. cGAS-STING pathway may play a key role in the occurrence and development of endometriosis by regulating autophagy. The combination of inhibitors targeting cGAS-STING with estrogen or surgery may become a therapeutic approach for endometriosis, and we present a review about the mechanism and physiological function of cGAS-STING pathway, typical autophagy and STING-dependent atypical autophagy, autophagy expression in endometriosis, and a new idea that cGAS-STING may be involved in endometriosis by regulating autophagy.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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