cGAS-STING pathway participates in endometriosis by up-regulating autophagy:Review.

Zhu S, sennan zhu, Chen Q, Qiu-yu Chen, Xinyi Du, Du X, Xu F, XU Fengming, Zongwen Liang, Liang Z, Yu Zhao, Zhao Y, Zhang Q, Qiong Zhang
In: Authorea, Inc. · 2020 · doi:10.22541/au.160372880.07417845/v1 · W4213351056
Review preprint OA: gold CC0 ⤵ 1 in-corpus citation
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This review explores how the cGAS-STING pathway might contribute to endometriosis by up-regulating autophagy, suggesting potential therapeutic strategies.

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Abstract

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthetase (cGAS) and its downstream interferon gene stimulator (STING) act as important immune monitoring media have become a research hotspot. cGAS-STING pathway may play a key role in the occurrence and development of endometriosis by regulating autophagy. The combination of inhibitors targeting cGAS-STING with estrogen or surgery may become a therapeutic approach for endometriosis, and we present a review about the mechanism and physiological function of cGAS-STING pathway, typical autophagy and STING-dependent atypical autophagy, autophagy expression in endometriosis, and a new idea that cGAS-STING may be involved in endometriosis by regulating autophagy.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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