Immunohistochemical expression of YKL-40 in peritoneal endometriosis

Pan Jo Kim, Dae Gy Hong, Ji Young Park, Young Lae Cho, Il Soo Park, Yoon Soon Lee
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2009 · vol. 26(1) , pp. 58–62 · doi:10.3109/09513590903184068 · PMID:19701838 · W2138052917
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YKL-40 was detected in the cytoplasm of epithelial cells in 63% of peritoneal endometriosis cases, and its expression was significantly related to endometriosis severity.

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Abstract

AIMS: To evaluate the relationship between the immunohistochemical expression of YKL-40 and peritoneal endometriosis by using paraffinized peritoneal tissue blocks. METHODS AND MATERIALS: We retrospectively collected data from 27 patients whose pathologic reports indicated invasion of the peritoneum by endometriosis. A conventional peroxidase staining technique was performed using rabbit polyclonal antibody (Quidel corporation, Santa Clara, CA) on peritoneal tissue blocks; their histology was then reviewed by a pathologist, and data were analyzed by nonparametric and Mann-Whitney tests. RESULTS: YKL-40 was detected immunohistochemically in 17 (63%) of 27 cases. The number of biopsies which were invaded by endometriosis (P = 0.015), with a score based on the revised classification of endometriosis (American Society for Reproductive Medicine) had statistical significance (P = 0.001). The obstetric history, age, body mass index, severity, and occurrence of dysmenorrhea, menstrual phase, preoperative CA 125, erythrocyte sedimentation rate, and white blood cell count had no statistical significance. YKL-40 immunoreactivity was recognized as brown staining, localized to the cytoplasm of epithelial cells of endometrial gland in peritoneal endometriosis. There was no positive staining on endometrial stromal cells or smooth muscle cells. CONCLUSIONS: YKL-40 is related to severity of peritoneal endometriosis. However why a different expression level of immunohistochemical staining should occur is not known and needs further investigation.

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Condition tags

endometriosisdysmenorrhea

MeSH descriptors

Endometriosis Glycoproteins Lectins Peritoneal Diseases Adipokines Adult Biomarkers Biomarkers Chitinase-3-Like Protein 1 Endometriosis Female Glycoproteins Humans Immunohistochemistry Lectins Middle Aged Peritoneal Diseases Retrospective Studies Severity of Illness Index Tissue Distribution

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