Serum adiponectin concentrations are decreased in women with endometriosis

Yuri Takemura, Takemura Y, Osuga Y, Yutaka Osuga, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Morimoto C, Chieko Morimoto, Yasushi Hirota, Osamu Yoshino, Yoshino O, Yano T, Tetsu Yano, Yuji Taketani, Taketani Y
Human Reproduction · 2005 · vol. 20(12) , pp. 3510–3513 · doi:10.1093/humrep/dei233 · PMID:16055459 · W2103534537
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This study found significantly lower serum adiponectin concentrations in women with endometriosis compared to those without, correlating negatively with endometriosis and adhesion scores.

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Abstract

BACKGROUND: Adiponectin is a pleiotropic cytokine originally discovered as an adipocyte-specific gene product. Serum adiponectin concentrations have been reported to be low in women with endometrial cancer, breast cancer and uterine leiomyoma, suggesting possible involvement of adiponectin in these estrogen-related diseases. We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study. METHODS: Women with (n = 48) and without (n = 30) endometriosis undergoing laparoscopy were recruited in this study. Blood samples were collected, and serum adiponectin concentrations were measured using a specific enzyme-linked immunosorbent assay. The relationship between laparoscopic findings and serum adiponectin concentrations was analysed. RESULTS: The adiponectin concentrations in the serum of the women with endometriosis (median, 13.1 microg/ml; interquartile range, 10.2 - 16.7) were significantly lower than those of the women without endometriosis (15.9 microg/ml, 13.5 - 19.5; P = 0.008). A significant negative correlation was found between serum adiponectin concentrations and both endometriosis scores (R = - 0.307, P = 0.006) and adhesion scores (R = - 0.254, P = 0.026) of the revised American Society for Reproductive Medicine classification of endometriosis. CONCLUSIONS: The present findings suggest that adiponectin is implicated in the pathophysiology of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adiponectin Endometriosis Endometriosis Gene Expression Regulation Gene Expression Regulation Adiponectin Adiponectin Adiponectin Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Humans Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

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