Association between endometriosis and risk of type 2 diabetes: Results from the prospective E3N cohort

Patricia Vaduva, Vaduva P, Nasser Laouali, Laouali N, Guy Fagherazzi, Fagherazzi G, Amandine Gelot, Gelot A, Fabrice Bonnet, Bonnet F, Marina Kvaskoff
Maturitas · 2023 · vol. 177 , pp. 107805 · doi:10.1016/j.maturitas.2023.107805 · PMID:37531871 · W4385296779
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study investigated the link between endometriosis and type 2 diabetes risk using data from the prospective E3N cohort.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

I can’t access the paper’s content here because the site blocks automated requests with a proof-of-work “Anubis” page, so I don’t have the study methods or results to summarize. If you paste the abstract and key results (or the full text), I can produce a 3–5 sentence biomedical summary that includes the stated caveats. The paper is about the association between endometriosis and risk of type 2 diabetes, and it is directly relevant to endometriosis research within the corpus. This paper is centrally about endometriosis — it examines how having endometriosis relates prospectively to later type 2 diabetes risk.

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Abstract

OBJECTIVE: Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes. STUDY DESIGN: E3N is a prospective cohort of 98,995 French women aged 40-65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status. RESULTS: Age at inclusion was 51 ± 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at inclusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92-1.29), neither after further adjustment for family history of diabetes, hypertension and menopausal status (HR = 0.97;95%CI = 0.80-1.16). The relationship did not differ by age at inclusion, BMI, infertility treatment, diet or menopausal status (p > 0.05). CONCLUSIONS: Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.
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Condition tags

endometriosis

MeSH descriptors

Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (8)

Source provenance

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License: CC0 · commercial use OK