The Relationship Between Endometrioma And Systemic Inflammation Indexes

Mehmet Alican Sapmaz, Murat Polat, Furkan Akın, Mine Büşra Pehlivan
In: Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi · 2025 · vol. 22(3) , pp. 316–320 · doi:10.38136/jgon.1575813 · W4414832625
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This study found no significant differences in systemic inflammation indices (SII, SIRI, PIV) between women with endometrioma and controls, suggesting endometrioma may cause localized rather than systemic inflammation.

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This retrospective case-control study evaluated whether isolated endometrioma induces systemic inflammation by comparing systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) in 213 patients with endometrioma against 207 healthy controls. The researchers found no statistically significant differences in these comprehensive inflammatory indices between the two groups, although CA-125 and CA 19-9 levels were significantly elevated in the endometrioma cohort. The authors conclude that endometrioma appears to cause primarily localized rather than systemic inflammation, while noting that the retrospective design and limited sample size constrain the generalizability of these findings. This paper is centrally about endometriosis — specifically investigating the systemic inflammatory profile associated with ovarian endometriomas.

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Abstract

Aim: Recent studies have examined systemic inflammatory markers like C-reactive protein (CRP) and fibrinogen, but the role of comprehensive indices such as the systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) in endometrioma remains unclear. This study aimed to evaluate whether isolated endometrioma stimulates systemic inflammation by assessing SII, SIRI, and PIV. Material and Methods: A retrospective case-control study was conducted involving 213 patients with endometrioma and 207 controls with no gynecological or systemic diseases. Data collected included age, CA-125, CA 19-9, platelet, neutrophil, lymphocyte, monocyte counts, and inflammatory indices (SII, SIRI, PIV). Statistical analysis was performed using the Student’s t-test. Results: No significant differences were found between the endometrioma group and the control group in terms of SII (970±146.6 vs. 753±471, p=0.121), SIRI (1.73±1.21 vs. 1.39±1.02, p=0.107), or PIV (551±420 vs. 419±313, p=0.100). CA-125 and CA 19-9 levels were significantly higher in the endometrioma group compared to controls (p=0.003 and p=0.020, respectively). Conclusion: The study did not find significant evidence that isolated endometrioma induces systemic inflammation based on SII, SIRI, and PIV. The findings suggest that endometrioma may primarily cause localized inflammation rather than systemic effects. Limitations include the retrospective design and relatively small sample size, which may affect the generalizability and causality of the results. Further prospective studies with larger cohorts are needed to fully understand the systemic inflammatory implications of endometrioma.
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Abstract

Aim: Recent studies have examined systemic inflammatory markers like C-reactive protein (CRP) and fibrinogen, but the role of comprehensive indices such as the systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) in endometrioma remains unclear. This study aimed to evaluate whether isolated endometrioma stimulates systemic inflammation by assessing SII, SIRI, and PIV.

Material and methods

A retrospective case-control study was conducted involving 213 patients with endometrioma and 207 controls with no gynecological or systemic diseases. Data collected included age, CA-125, CA 19-9, platelet, neutrophil, lymphocyte, monocyte counts, and inflammatory indices (SII, SIRI, PIV). Statistical analysis was performed using the Student’s t-test.

Results

No significant differences were found between the endometrioma group and the control group in terms of SII (970±146.6 vs. 753±471, p=0.121), SIRI (1.73±1.21 vs. 1.39±1.02, p=0.107), or PIV (551±420 vs. 419±313, p=0.100). CA-125 and CA 19-9 levels were significantly higher in the endometrioma group compared to controls (p=0.003 and p=0.020, respectively).

Conclusion

The study did not find significant evidence that isolated endometrioma induces systemic inflammation based on SII, SIRI, and PIV. The findings suggest that endometrioma may primarily cause localized inflammation rather than systemic effects. Limitations include the retrospective design and relatively small sample size, which may affect the generalizability and causality of the results. Further prospective studies with larger cohorts are needed to fully understand the systemic inflammatory implications of endometrioma.

Keywords

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References

- 1 Jiang L, Yan Y, Liu Z, Wang Y. Inflammation and endometriosis. Front Biosci (Landmark Ed). 2016 Jun 1;21(5):941-8. doi: 10.2741/4431. PMID: 27100482. 2 Leiva MC, Hasty LA, Lyttle CR: Inflammatory changes of the endometrium in patients with minimal-to-moderate endometriosis. Fertil Steril 62(5):967-72 (1994) Details Primary Language English Subjects Obstetrics and Gynaecology Journal Section Research Article Publication Date September 30, 2025 Submission Date October 31, 2024 Acceptance Date May 30, 2025 Published in Issue Year 2025 Volume: 22 Number: 3 APA Sapmaz, M. A., Polat, M., Akın, F., & Bozkürk, M. B. (2025). The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi, 22(3), 316-320. https://doi.org/10.38136/jgon.1575813 AMA 1.Sapmaz MA, Polat M, Akın F, Bozkürk MB. The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2025;22(3):316-320. doi:10.38136/jgon.1575813 Chicago Sapmaz, Mehmet Alican, Murat Polat, Furkan Akın, and Mine Büşra Bozkürk. 2025. “The Relationship Between Endometrioma And Systemic Inflammation Indexes”. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi 22 (3): 316-20. https://doi.org/10.38136/jgon.1575813. EndNote Sapmaz MA, Polat M, Akın F, Bozkürk MB (September 1, 2025) The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 22 3 316–320. IEEE [1]M. A. Sapmaz, M. Polat, F. Akın, and M. B. Bozkürk, “The Relationship Between Endometrioma And Systemic Inflammation Indexes”, Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, vol. 22, no. 3, pp. 316–320, Sept. 2025, doi: 10.38136/jgon.1575813. ISNAD Sapmaz, Mehmet Alican - Polat, Murat - Akın, Furkan - Bozkürk, Mine Büşra. “The Relationship Between Endometrioma And Systemic Inflammation Indexes”. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 22/3 (September 1, 2025): 316-320. https://doi.org/10.38136/jgon.1575813. JAMA 1.Sapmaz MA, Polat M, Akın F, Bozkürk MB. The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2025;22:316–320. MLA Sapmaz, Mehmet Alican, et al. “The Relationship Between Endometrioma And Systemic Inflammation Indexes”. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi, vol. 22, no. 3, Sept. 2025, pp. 316-20, doi:10.38136/jgon.1575813. Vancouver 1.Mehmet Alican Sapmaz, Murat Polat, Furkan Akın, Mine Büşra Bozkürk. The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2025 Sep. 1;22(3):316-20. doi:10.38136/jgon.1575813

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