{"paper_id":"f8ca1184-be13-4513-9e44-554ae8723f94","body_text":"EN\nTR\nThe Relationship Between Endometrioma And Systemic Inflammation Indexes\nAbstract\nAim: Recent studies have examined systemic inflammatory markers like C-reactive protein (CRP) and fibrinogen, but the role of comprehensive indices such as the systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) in endometrioma remains unclear. This study aimed to evaluate whether isolated endometrioma stimulates systemic inflammation by assessing SII, SIRI, and PIV.\nMaterial and Methods: A retrospective case-control study was conducted involving 213 patients with endometrioma and 207 controls with no gynecological or systemic diseases. Data collected included age, CA-125, CA 19-9, platelet, neutrophil, lymphocyte, monocyte counts, and inflammatory indices (SII, SIRI, PIV). Statistical analysis was performed using the Student’s t-test.\nResults: No significant differences were found between the endometrioma group and the control group in terms of SII (970±146.6 vs. 753±471, p=0.121), SIRI (1.73±1.21 vs. 1.39±1.02, p=0.107), or PIV (551±420 vs. 419±313, p=0.100). CA-125 and CA 19-9 levels were significantly higher in the endometrioma group compared to controls (p=0.003 and p=0.020, respectively).\nConclusion: The study did not find significant evidence that isolated endometrioma induces systemic inflammation based on SII, SIRI, and PIV. The findings suggest that endometrioma may primarily cause localized inflammation rather than systemic effects. Limitations include the retrospective design and relatively small sample size, which may affect the generalizability and causality of the results. Further prospective studies with larger cohorts are needed to fully understand the systemic inflammatory implications of endometrioma.\nKeywords\nSupporting Institution\nyok\nProject Number\nyok\nEthical Statement\nÇalışmamız için etik kurul izni alınmıştır\nReferences\n- 1 Jiang L, Yan Y, Liu Z, Wang Y. Inflammation and endometriosis. Front Biosci (Landmark Ed). 2016 Jun 1;21(5):941-8. doi: 10.2741/4431. PMID: 27100482. 2 Leiva MC, Hasty LA, Lyttle CR: Inflammatory changes of the endometrium in patients with minimal-to-moderate endometriosis. Fertil Steril 62(5):967-72 (1994)\nDetails\nPrimary Language\nEnglish\nSubjects\nObstetrics and Gynaecology\nJournal Section\nResearch Article\nPublication Date\nSeptember 30, 2025\nSubmission Date\nOctober 31, 2024\nAcceptance Date\nMay 30, 2025\nPublished in Issue\nYear 2025 Volume: 22 Number: 3\nAPA\nSapmaz, M. A., Polat, M., Akın, F., & Bozkürk, M. B. (2025). The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi, 22(3), 316-320. https://doi.org/10.38136/jgon.1575813\nAMA\n1.Sapmaz MA, Polat M, Akın F, Bozkürk MB. The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2025;22(3):316-320. doi:10.38136/jgon.1575813\nChicago\nSapmaz, Mehmet Alican, Murat Polat, Furkan Akın, and Mine Büşra Bozkürk. 2025. “The Relationship Between Endometrioma And Systemic Inflammation Indexes”. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi 22 (3): 316-20. https://doi.org/10.38136/jgon.1575813.\nEndNote\nSapmaz MA, Polat M, Akın F, Bozkürk MB (September 1, 2025) The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 22 3 316–320.\nIEEE\n[1]M. A. Sapmaz, M. Polat, F. Akın, and M. B. Bozkürk, “The Relationship Between Endometrioma And Systemic Inflammation Indexes”, Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, vol. 22, no. 3, pp. 316–320, Sept. 2025, doi: 10.38136/jgon.1575813.\nISNAD\nSapmaz, Mehmet Alican - Polat, Murat - Akın, Furkan - Bozkürk, Mine Büşra. “The Relationship Between Endometrioma And Systemic Inflammation Indexes”. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 22/3 (September 1, 2025): 316-320. https://doi.org/10.38136/jgon.1575813.\nJAMA\n1.Sapmaz MA, Polat M, Akın F, Bozkürk MB. The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2025;22:316–320.\nMLA\nSapmaz, Mehmet Alican, et al. “The Relationship Between Endometrioma And Systemic Inflammation Indexes”. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi, vol. 22, no. 3, Sept. 2025, pp. 316-20, doi:10.38136/jgon.1575813.\nVancouver\n1.Mehmet Alican Sapmaz, Murat Polat, Furkan Akın, Mine Büşra Bozkürk. The Relationship Between Endometrioma And Systemic Inflammation Indexes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2025 Sep. 1;22(3):316-20. doi:10.38136/jgon.1575813","source_license":"CC0","license_restricted":false}