Increased chemotactic activity of peritoneal fluid in patients with endometriosis
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Peritoneal fluid from endometriosis patients exhibited increased chemotactic activity compared to controls, indicating a potential role for chemoattractants in the pathogenesis of the disease.
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Abstract
OBJECTIVE: Our purpose was to investigate the ability of the peritoneal fluid of patients with endometriosis to induce chemotaxis of neutrophils and macrophages.
STUDY DESIGN: Peritoneal fluid samples of patients with endometriosis (n = 20), normal fertile controls (n = 12), or patients with medical suppression (n = 8) were evaluated for chemotactic activity. Results of chemotactic activity were analyzed by analysis of variance.
RESULTS: Peritoneal fluid of patients with endometriosis demonstrated a significantly higher chemotactic activity than that of patients without endometriosis or with medical suppression. Patients who had received medical treatment had the lowest chemotactic activity. (p < 0.001 for endometriosis vs control or treatment patients, p = 0.005 for control group vs treatment group).
CONCLUSIONS: Patients with endometriosis have a higher chemotactic activity in their peritoneal fluid; prior medical treatment significantly reduces this activity. This chemotactic factor has an estimated weight of 20 kd. The nature and source of this chemotactic factor remains to be determined.
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Cited by (40)
- Biomaterial Tools for Modeling Endometriosis 2026
- Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis 2022
- Peritoneal macrophages - the key link in development, progression and mantaining of endometriotic lesions and formation of endometriosis-associated infertility 2019
- Pathogenesis of Endometriosis: Roles of Retinoids and Inflammatory Pathways 2015
- The impact of endometriosis on fertility 2015
- Aromatase and endometriosis: estrogens play a role 2014
- A tumor necrosis factor-α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid 2013
- Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis 2013
- Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects 2013
- Peritoneal fluid from endometriosis patients switches differentiation of monocytes from dendritic cells to macrophages 2007
- Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes 2006
- A baboon model for endometriosis: implications for fertility 2006
- Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis 2006
- Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid 2003
- Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay 2002
- Molecular mechanisms contributing to the pathogenesis of endometriosis 2002
- Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis 2002
- Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis 2002
- Signal transduction pathways involved in macrophage migration induced by peritoneal fluid chemotactic factors in stages I and II endometriosis 2002
- Uterine chemokines in reproductive physiology and pathology 2002
- The fallopian tube and reproductive health 1999
- Chemokines and human reproduction 1999
- Pathogenesis of endometriosis: the role of peritoneal fluid 1999
- Endometriotic disease: the role of peritoneal fluid 1998
- Macrophage scavenger receptor(s) and oxidatively modified proteins in endometriosis 1998
- Lysophosphatidyl choline, a chemotactic factor for monocytes/T-lymphocytes is elevated in endometriosis 1998
- Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells 1997
- Angiogenesis and macrophage activation in endometriosis 1997
- Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells 1997
- Increased expression of complement component 3 in human ectopic endometrium compared with the matched eutopic endometrium 1997
- Monocyte chemotactic protein-l concentration of in in peritoneal fluid women with endometriosis and its modulation mesothelial cells* 1997
- Basic research in endometriosis 1997
- Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis 1997
- Growth-regulated alpha expression in the peritoneal environment with endometriosis 1996
- Increased monocyte chemotactic protein-1 level and activity in the peripheral blood of women with endometriosis. Le Groupe d'Investigation en Gynécologie 1996
- The peritoneal environment in endometriosis 1996
- Peritoneal growth factors and endometriosis 1996
- Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture. The Groupe d'Investigation en Gynécologie 1995
- Immunohistochemical localization of granulocyte-macrophage colony-stimulating factor in matched endometriosis and endometrial tissues 1994
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