Autoimmune phenomena in infertile patients with endometriosis

Shawky Z.A. Badawy, Violeta Cuenca, Ann Stitzel, Reinhilde Jacobs, R H Tomar
In: Diagnosis and Management of Tubo-Uterine Factors in Infertility · 1984 · pp. 101–102 · doi:10.1007/978-94-011-7621-7_20 · W4300936532
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This study investigated complement components and immunoglobulins in the peritoneal fluid and serum of infertile patients with endometriosis compared to controls.

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The paper studies complement system components (C3c, C4, properdin, factor B) and immunoglobulins in the peritoneal fluid and serum of infertile patients with endometriosis, comparing results with infertile patients without evidence of endometriosis. Building on prior reports suggesting immune activation in endometriosis, the authors interpret their measurements as evidence relevant to an autoimmune reaction involving complement activation. A major limitation is that the provided text does not include the actual concentrations or statistical results, so the direction and magnitude of group differences cannot be verified from the excerpt. This paper is centrally about endometriosis — it examines complement components and immunoglobulins in infertile patients to characterize proposed autoimmune phenomena associated with endometriosis.

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Abstract

Recent data in the literature suggest that endometriosis may lead to an autoimmune reaction. This is supported by the presence of excess macrophage reaction in the peritoneal fluid of these patients1. In addition, immunofluorescence studies have shown the presence of complement component C3 in the endometrium of patients with endometriosis2. It has been hypothesized that protein substances from the ectopic endometrial tissue is recognized as foreign and stimulate the immune reaction. The present study examines the concentration of complement components C3c and C4, properdin, factor B, and immunoglobulins in the peritoneal fluid and serum of infertile patients with endometriosis. The results are compared with those with no evidence of endometriosis. Similar content being viewed by others

References

Haney, A. F., Muscato, J. J. and Weinberg, J. B. (1981). Peritoneal fluid cell populations in infertility patients. Fertil. Steril., 35, 696 Weed, J. C. and Arquembroug, P. C. (1980). Endometriosis: Can it produce an autoimmune response resulting in infertility? Clin. Obstet. Gynecol., 23, 885 Cooper, N. R. (1980). The complement system. In Fundenberg, H. H., Stites, D. P., Caldwell, J. L. and Wells, J. V. (eds.) Basic and Clinical Immunology. 3rd Edn. pp. 83–95. (Los Altos, Ca.: Lange Medical Publications) Editor information Editors and Affiliations Rights and permissions Copyright information © 1984 MTP Press Limited About this chapter Cite this chapter Badawy, S.Z.A., Cuenca, V., Stitzel, A., Jacobs, R.D.B., Tomar, R.H. (1984). Autoimmune phenomena in infertile patients with endometriosis. In: Harrison, R.F., Bonnar, J., Thompson, W. (eds) Diagnosis and Management of Tubo-Uterine Factors in Infertility. Studies in Fertility and Sterility, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7621-7_20 Download citation DOI: https://doi.org/10.1007/978-94-011-7621-7_20 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-011-7623-1 Online ISBN: 978-94-011-7621-7 eBook Packages: Springer Book Archive

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endometriosis

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