Identifying the presence of antibodies against endometrial antigens. A preliminary study.
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This study found a 34-kd endometrial antigen recognized by serum and peritoneal fluid antibodies that is specific to endometriosis, potentially aiding diagnosis.
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Abstract
Serum and peritoneal fluid from women with and without evidence of endometriosis were tested for the presence of antibodies against endometrial tissue antigens with Western blot analysis. Serum antibodies against endometrial cytosolic antigens of molecular weight 45, 52, 58, 62 and 66 kd were present in samples obtained from women both with and without endometriosis. The patients with endometriosis had serum antibodies against 34-kd endometrial cytosolic antigen, which was not present in serum from fertile women without endometriosis. The peritoneal fluid from patients with endometriosis also reacted with 34-kd endometrial antigen but not the peritoneal fluid from control fertile women. There was no difference in the antigens detected with serum antibody when endometrium from fertile women without evidence of endometriosis and from women with endometriosis was used as a source of antigen. The presence of serum antibody against 34-kd endometrial antigen is specific to endometriosis. However, this antigen is expressed by endometrium of women both with or without endometriosis. Isolation and identification of this antigen may lead to development of a noninvasive aid for the diagnosis of endometriosis.
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Cited by (15)
- Prevalent innate and adaptive immune mechanisms in endometriosis 2021
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Endometriosis and Autoimmunity 2011
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Clinical Observation of Chinese Medicine Treatment on Secondary Dysmenorrhoea Associated with Endometriosis 2009
- Multiple endometrial antigens are targeted in autoimmune endometriosis 2008
- Serum Antiendometrial Antibodies and Diagnosis of Endometriosis 2007
- Antiendometrial antibodies and endometriosis 2002
- Is endometriosis an endometrial disease? 2000
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Immunology of endometriosis 1999
- A preliminary immunopharmacological study of an antiendometriotic herbal medicine, Keishi-bukuryo-gan. 1998
- Immunoblot Detection of Decreased Antibodies to Haptoglobin-Like Protein in the Serum of Infertile Women with or without Endometriosis1 1997
- Endometriosis: Soluble CD23 protein in the peritoneal fluid of patients with endometriosis 1996
- Immunological aspects of endometriosis 1996
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- openalex
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