Difference in the presence of cell-mediated and humoral immunity in patients with endometriosis compared with healthy women

Nina Slabe, Renata Košir Pogačnik, Robert Pantar, Alenka Vizjak, Alojz Ihan, Martina Ribič Pucelj, Špela Smrkolj, Helena Meden Vrtovec
In: Zdravniški Vestnik, Vol 80, Iss 7-8 (2011) · 2011 · W1885538275
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This study found that endometriosis patients had higher rates of allergies and a statistically significant difference in regulated T lymphocytes compared to controls, along with the presence of antiendothelial antibodies.

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This prospective study compared 60 women with endometriosis to 49 healthy women, using immunological analyses to evaluate cell-mediated and humoral immune components. On the humoral level, the authors measured antiovary, antiendometrial, and antiendothelial antibodies and found that five endometriosis patient sera were positive for antiendothelial antibodies reacting with vascular endothelium, while allergies were more frequent among patients. On the cell level, there was a statistically significant difference between groups in the proportion of regulated T lymphocytes (CD3+ CD25++) in peripheral blood (p = 0.025). The authors note that their findings did not fully confirm their broader hypothesis of immune response alterations. This paper is centrally about endometriosis — it investigates differences in cell-mediated (regulated T-cell proportions) and humoral (antiendothelial antibody reactivity) immunity between women with endometriosis and healthy controls.

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Abstract

Background: Endometriosis is often defined as heterogeneous immune abnormality. In accordance with the data, women with endometriosis are more frequently affected by Hashimoto’s thyroiditis, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arhritis, asthma, eczema and have increased activity of policlonal B-cells, abnormal acitvity of T- and B-lymphocytes, decreased activity of natural killer cells and presence of antiendometrial antibodies. In our study, we tried to define the disease in the context of other autoimmune diseases and determine the type of immune abnormality. Methods: In the prospective study 60 females with endometriosis were inluded in the study group and 49 healthy females in the control group. The presence of endometriosis in the complex of other autoimmune diseases was evaluated by targeted family, personal and reendomeproductive history. The type of immune abnormality was evaluated by immunological analysis on the cell level: subtypisation of lymphocytes, cytotoxic and regulatory T cells and NK cells. On the humoral level, we defined antiovary, antiendometrial and antiendothelial antibodies. The results were statistically evaluated using the Pearson’s Chi-square test and Mann – Whitney test. Results: Patients with endometriosis are more frequently affected by allergies (p = 0.039). Five serums of endometriosis patients were positive for antiendothelial antibodies specifically reacting with vascular endothelium. There was statistically significant diference between the study and the control group in the proportion of regulated T lymphocytes (CD3+ CD25++) in the pherypheral blood (p = 0.025). Conclusions: We have not fully confirmed the hypothesis that women with endomeriosis have alterations in the immune response. However, the present study supports and adds important infomation to the views that immune abnormality plays an important role in the etiopathogenesis of endometriosis. On the humoral level, we showed the presence of antiendothelial antibodies reacting with vascular endothelium.
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Zdravniški Vestnik (Aug 2011) Difference in the presence of cell-mediated and humoral immunity in patients with endometriosis compared with healthy women Abstract Background: Endometriosis is often defined as heterogeneous immune abnormality. In accordance with the data, women with endometriosis are more frequently affected by Hashimoto’s thyroiditis, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arhritis, asthma, eczema and have increased activity of policlonal B-cells, abnormal acitvity of T- and B-lymphocytes, decreased activity of natural killer cells and presence of antiendometrial antibodies. In our study, we tried to define the disease in the context of other autoimmune diseases and determine the type of immune abnormality. Methods: In the prospective study 60 females with endometriosis were inluded in the study group and 49 healthy females in the control group. The presence of endometriosis in the complex of other autoimmune diseases was evaluated by targeted family, personal and reendomeproductive history. The type of immune abnormality was evaluated by immunological analysis on the cell level: subtypisation of lymphocytes, cytotoxic and regulatory T cells and NK cells. On the humoral level, we defined antiovary, antiendometrial and antiendothelial antibodies. The results were statistically evaluated using the Pearson’s Chi-square test and Mann – Whitney test. Results: Patients with endometriosis are more frequently affected by allergies (p = 0.039). Five serums of endometriosis patients were positive for antiendothelial antibodies specifically reacting with vascular endothelium. There was statistically significant diference between the study and the control group in the proportion of regulated T lymphocytes (CD3+ CD25++) in the pherypheral blood (p = 0.025). Conclusions: We have not fully confirmed the hypothesis that women with endomeriosis have alterations in the immune response. However, the present study supports and adds important infomation to the views that immune abnormality plays an important role in the etiopathogenesis of endometriosis. On the humoral level, we showed the presence of antiendothelial antibodies reacting with vascular endothelium.

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