{"paper_id":"b7a73416-1ed8-4b30-8afb-46239358fc29","body_text":"Abstract\nPurpose\nAfter noticing specific aberrant forms of development in preimplantation embryos from women with endometriosis, we embarked upon this study in order to examine the frequency of these events as compared with controls.\nMethods\nA total of 235 embryos representing 30 women undergoing 56 cycles of in vitrofertilization were retrospectively analyzed on videotape and placed into categories based upon the incidence of specific morphological criteria found during observations made on the first and second days following oocyte retrieval.\nResults\nSeveral of the aberrant nuclear and cytoplasmic events were found to be statistically increased in the group of embryos from women with endometriosis.\nConclusions\nThe incidence of defined aberrant phenotypes in embryos from women with laparoscopically documented endometriosis may allow us to identify specific embryotoxic events with reference to endometriosis and other diagnoses.\nSimilar content being viewed by others\nReferences\nRon-El R, Nachum H, Herman A, Golan A, Caspi E, Soffer Y: Delayed fertilization and poor embryonic development associated with impaired semen quality. Fertil Steril 1991;55:338–344\nPrainaud J, Mieusset R, Vieitez G, Labal B, Richoilley G: Influence of sperm parameters on embryo quality. Fertil Steril 1993;60:888–892\nFishel S, Jackson P, Webster J, Faratian B: Endotoxins in culture medium for human in vitro fertilization. Fertil Steril 1988;49:108–111\nVasquez-Levin M, Kaplan P, Guzman I, Grunfeld L, Garrisi GJ, Navot D: The effect of female antisperm antibodies on in vitro fertilization, early embryonic development, and pregnancy outcome. Fertil Steril 1991;56:84–88\nMichaeli G, Fejgin M, Ghetler Y, Ben Nun I, Beyth Y, Amiel A: Chromosomal analysis of unfertilized oocytes and morphologically abnormal preimplantation embryos from an in vitro fertilization program. J in Vitro Fertil Embryo Transfer 1990;7:341–346\nDamewood MD, Hesla JS, Schlaff WD, Hubbard M, Gearhart JD, Rock JA: Effect of serum from patients with minimal to mild endometriosis on mouse embryo development in vitro. Fertil Steril 1990;54:917–920\nSimon C, Gomez E, Mir A, De los Santos M, Pellicer A: Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients. Fertil Steril 1992;58:284–289\nMorcos RN, Gibbons WE, Findley WE: Effect of peritoneal fluid on in vitro cleavage of 2-cell mouse embryos: possible role in infertility associated with endometriosis. Fertil Steril 1985:44:678–683\nRemohi J, Vidal A, Pellicer A: Oocyte donation in low level responders to conventional ovarian stimulation for in vitro fertilization. Fertil Steril 1993:59:1208–1215\nShulman A, Ben-Nun I, Ghetler Y, Kaneti H, Shilon M, Beyth Y: Relationship between embryo morphology and implantation rate after in vitro fertilization treatment in conception cycles. Fertil Steril 1993;60:123–126\nSimon C, Gutierrez A, Vidal A, de los Santos MJ, Tarin JJ, Remohi J, Pellicer A: Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 1994;9:725–729\nMahmood TA, Messinis IE, Templeton A: Follicular development in spontaneous and stimulated cycles in women with minimal-mild endometriosis. Br J Obstet Gynaecol 1991;98: 783–788\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nBrizek, C.L., Schlaff, S., Pellegrini, V.A. et al. Increased incidence of aberrant morphological phenotypes in human embryogenesis—An association with endometriosis. J Assist Reprod Genet 12, 106–112 (1995). https://doi.org/10.1007/BF02211378\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF02211378","source_license":"CC0","license_restricted":false}