Comparison of Menstrual Effluent Vascular Endothelial Growth Factor Immunocytochemistry Expression Between Endometriosis and Non-Endometriosis Patients

Jul 2021, Vol 9, Issue 3 Advanced Search For Author's & Reviewer's Poll How do you find the scientific quality of the published articles on our web site? | Original Article | | | Comparison of Menstrual Effluent Vascular Endothelial Growth Factor Immunocytochemistry Expression Between Endometriosis and Non-Endometriosis Patients | | | Ruswana Anwar, Sunardi, Siti Salima, Setyorini Irianti, Benny Hasan Purwara, Tono Djuwantono, Wiryawan Permadi, Tita Husnitawati Madjid | | | Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia | | | IJWHR 2021; 9: 182-189 DOI: 10.15296/ijwhr.2021.34 Viewed : 4012 times Downloaded : 3532 times. Keywords : Endometriosis, VEGF, Pain, Cyst size, Infertility | | | Full Text(PDF) | Related Articles | | | Abstract | | Objectives: This study aimed to measure the vascular endothelial growth factor (VEGF) expression in menstrual effluent from patients with endometriosis compared to non-endometriosis through immunocytochemical methods. We also measured the degree of pain level, endometrioma cyst size, and infertility status whether it is affected by VEGF expression. Materials and Methods: The present case-control study was conducted in Hasan Sadikin General Hospital, Bandung. Thirty productive-age women diagnosed with endometrioma and 30 productive-age women without endometriosis as the control group were included in this study. Menstrual effluent was taken from the posterior fornix on the second day of menstruation and stained using immunocytochemistry staining for VEGF. Results: The results demonstrated a significant difference between the two study groups in terms of VEGF intensity and histoscore although no difference was found in VEGF distributions between the study groups. The subjects in the endometriosis group had significantly higher VEGF intensity and significantly higher VEGF histoscore compared to the control group. Women with VEGF histoscore more than 6 has 9.33 times risk of developing endometriosis compared to those with lower histoscore. There were no significant correlations between VEGF and pain scale, infertility, and the cyst size. Finally, the cyst size was proportionally related to pain. Conclusions: VEGF distribution and expression in endometriosis women were significantly higher than VEGF levels in non-endometriosis women. Women with menstrual effluent containing higher VEGF levels had more chances of developing endometriosis compared to those with lower VEGF levels. Eventually, larger endometrioma size was proportionally related to higher pain levels in subjects with endometrioma. | Cite By, Google Scholar Articles by Anwar R Articles by Sunardi S Articles by Salima S Articles by Irianti S Articles by Hasan Purwara B Articles by Djuwantono T Articles by Permadi W Articles by Husnitawati Madjid T Articles by Ruswana Anwar Articles by Sunardi Articles by Siti Salima Articles by Setyorini Irianti Articles by Benny Hasan Purwara Articles by Tono Djuwantono Articles by Wiryawan Permadi Articles by Tita Husnitawati Madjid Submit Paper Online Submission System IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal Online Submission System IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal Publication Information Publisher Aras Part Medical International Press Editor-in-Chief Arash Khaki Mertihan Kurdoglu Deputy Editor Zafer Akan Aras Part Medical International Press Editor-in-Chief Arash Khaki Mertihan Kurdoglu Deputy Editor Zafer Akan Published Article Statistics