Wiryawan Permadi

OBJECTIVE: Endometriosis is a chronic gynecological disease associated with inflammation and severe pelvic pain in 6%-10% of women of reproductive age. Although the pathophysiology and management of endometriosis are currently understood, f…

Endometriosis is an enigmatic disease affecting approximately 10% of the population. This unique disease is often chronic and characterized by inflammation. Even though endometriosis and its related disease, adenomyosis, are benign tumors, …

Aims: To explore early symptoms and lived experiences of endometriosis during adolescence, as recalled by adult women diagnosed with endometriosis, to identify indicators for a screening questionnaire for high school girls.Background: Endom…

Kallmann syndrome (KS) is a rare genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. This case report highlights a 30-year-old woman with KS who presented with secondary amenorrhea and uterine hypoplasia after repea…

Purpose: Adenomyosis is a complex uterine condition, with emerging evidence indicating epigenetic alterations play a role in its pathogenesis. The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T may reduce enzyme activit…

Martin Hermawan,1 Dian Tjahyadi,1 Anita Rachmawati,1 Wiryawan Permadi,1 Hanom Husni Syam,1 Anom Suardika,2 Ruswana Anwar11Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hasan Sadikin General…

PURPOSE: Adenomyosis is a complex uterine condition, with emerging evidence indicating epigenetic alterations play a role in its pathogenesis. The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T may reduce enzyme activit…

INTRODUCTION: Premature ovarian insufficiency (POI) leads to the early loss of ovarian function before age 40, resulting in infertility and hormonal imbalance. Despite the use of assisted reproductive technologies (ART), success rates remai…

BACKGROUND: Endometriosis involves the presence of endometrial-like tissue outside the uterus, driven by inflammatory pathways including elevated interleukin-32 and vascular endothelial growth factor. One potential anti-inflammatory agent i…

Background: Endometriosis is a chronic gynecological disorder characterized by the presence of endometriosis-like tissue outside the uterine cavity, leading to pelvic pain, infertility, and other reproductive complications. Emerging evidenc…

OBJECTIVE: This study aimed to investigate the levels of chitinase-3-like protein-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9), and monocyte chemoattractant protein-1 (MCP-1) in adenomyosis, as compared to normal myometrial tissue. These …

Vitamin D and calcium in follicular fluid play an important role in modulating steroidogenesis, folliculogenesis, and oocyte quality determination. Both collaborate to produce top-quality embryos (TQE) during in vitro fertilization (IVF). I…

Abstract Endometriosis involves the presence of endometrial-like tissue outside the uterus, driven by inflammatory pathways including elevated Interleukin-32 (IL-32) and Vascular Endothelial Growth Factor (VEGF). One potential anti-inflamm…

BACKGROUND: Low birth weight (LBW) is a risk factor associated with endometriosis. Our study aimed to analyze the risk of endometriosis in women with a LBW history and the relationships of progesterone receptor B (PR-B) gene promoter methyl…

Objectives: This study aimed to examine the effect of a laparoscopic cystectomy on ovarian reserve assessed by measuring the levels of serum follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH). Materials and Methods: This pr…

BACKGROUND: Endometriosis has a major impact on women's quality of life. The two primary pathologies are chronic inflammation and altered apoptotic activity. Sulawesi propolis has been shown to have known anti-inflammatory and pro-apoptotic…

BACKGROUND: This study aims to determine whether there is an effect of oocyte denudation time and ICSI time on embryo quality at assisted reproductive Technology clinic. METHODS: An observational analytic retrospective study was conduct us…

Adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium. Endometrial like cells development was influenced by local inflammatory reactions, increases local estradiol due t…

BACKGROUND: This study was conducted to determine the correlation of anti-Mullerian hormone (AMH) level and antral follicle count (AFC) with oocyte count in women who had received controlled ovarian hyperstimulation in an in vitro fertiliza…

BACKGROUND: The correlation between endometrioma and serum Anti-mullerian hormone (AMH) level is a benchmark in determining the prognosis and management of endometrioma. Endometrioma causes a decrease in ovarian reserve due to tissue damage…

OBJECTIVE: To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. RESULTS: This was retrospective study using secondary data of IVF patien…

Objectives: This study aimed to measure the vascular endothelial growth factor (VEGF) expression in menstrual effluent from patients with endometriosis compared to non-endometriosis through immunocytochemical methods. We also measured the d…

Endometriosis is a gynecological disease characterized by the presence of endometrial-like tissue outside the uterine cavity. Remodeling of the extracellular matrix (ECM) is a prerequisite for tissue implantation. The presence of matrix met…

BACKGROUND AND PURPOSE: The prevalence of tuberculosis (TB) in Indonesia is still high, whereas the prevalence of extra pulmonary tuberculosis such as female genital tuberculosis (FGTB) affecting infertility is unknown. FGTB caused irrevers…

Background: Endometriosis is a progressive chronic gynecological disease. There are indications that endometriosis patients have lower progesterone receptor B (PR-B) levels. Menstrual blood contains the same mRNA derived from endometrium ce…