Correlation between Estrogen Receptorβ (ERβ), Neurofilament Protein (NF), and Protein Gene Product 9.5 (PGP9.5) Expressions as a Marker of Pain on Adenomyosis Etiopathogenesis

Arief Setiawan, Ruswana Anwar, Tita Husnitawati, Tono Djuwantono, Wiryawan Permadi
In: Majalah Kedokteran Bandung · 2021 · vol. 53(4) , pp. 215–222 · doi:10.15395/mkb.v53n4.2363 · W4210336767
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⚙ AI-generated summary by claude@2026-06, 2026-06-19 ⓘ

Adenomyosis tissues showed higher expressions of ERβ, NF, and PGP 9.5, which were significantly correlated and positively associated with pain in adenomyosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

The provided text does not include the actual research content of the paper (e.g., study design, patient population, methods, results, or stated limitations); instead it contains repeated journal platform upgrade and cybersecurity recovery notices unrelated to scientific findings. Because the study details are missing, the key finding and any explicit caveats cannot be determined from the supplied material. This paper is centrally about adenomyosis — it is titled as investigating correlations among ERβ, NF, and PGP9.5 as markers related to adenomyosis etiopathogenesis of pain, though the underlying results are not included in the text you provided.

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Abstract

Adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium. Endometrial like cells development was influenced by local inflammatory reactions, increases local estradiol due to asynchromatized estrogen synthesis (ERβ) and then stimulated to proliferation and fibrosis, are also irritation on small nerve fibers in women with painful characterized symptoms on adenomyosis. There are expressions of neurofilament protein (NF) and protein gene product 9.5 (PGP 9.5) is a highly specific pan-neuronal marker for microfilament nerve fibers and is related to presenting pain with adenomyosis symptoms. A retrospective immunohistochemical study of thirty samples histopathological of adenomyosis as study groups and 30 with control groups between 25–49 ages which were established at Dr. Hasan Sadikin General Hospital and the satellites in April 2014–May 2015. This case-control analyzed ERβ, NF, and PGP 9.5 expressions compared and correlation between study groups and controls. The results showed there were significant differences in expression of ERβ, NF, and PGP 9.5 on adenomyosis higher than the control study (p<0.05). The intensity was higher and very strong into the study groups (p6(sensitivity 66.7%; specificity 70%), NF>3 (sensitivity 93%; specificity 46%), PGP 9.5>4 (sensitivity 90%; specificity 67%). Odds Ratio (CI 95%) ERβ>6= 4.67; NF >3=12.25; PGP 9.5 >4=24.75 (p<0.001). The value of histoscore of ERβ and PGP9.5 have correlates to adenomyosis, the differences were statistically significant (p<0.05). The conclusion were that the adenomyosis had higher ERβ, NF, and PGP 9.5 expressions. There are simultant correlates and positive values between ERβ, NF, and PGP9.5 based on etiophatogenesis of pain on adenomyosis.
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