Heterogeneous appearance of VEGF (vascular endothelial growth factor) immunopositivity in cyst capsules of endometrioma

Görkem Tuncay, Gorkem Tuncay, Tuncay G, Sevtap Kılıç, Sevtap Kilic, Kilic S, Yuksel B, Beril Yüksel, Beril Yuksel, Çiğdem Elmas, Elmas C, Cigdem Elmas, Neşe Lortlar, Lortlar N, Nese Lortlar, Erdogan D, Deniz Erdogan, Deniz Erdoğan, Ozogul C, Candan Özoğul, Candan Ozogul
Acta histochemica · 2008 · vol. 111(1) , pp. 61–67 · doi:10.1016/j.acthis.2008.04.005 · PMID:18556049 · W2022031998
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This study investigated the heterogeneous appearance of VEGF immunopositivity within the cyst capsules of endometriomas.

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Abstract

The aim of the research was to reveal vascular endothelial growth factor (VEGF) immunolocalization in endometrioma cysts and endometrial tissues. The study group (group1) included 15 patients laparoscopically operated on for endometrioma and the control group (group 2) included 13 patients prepared for diagnostic laparoscopy for primary infertility. Biopsies from endometrioma cyst capsules, disease-free peritoneum and pipelle biopsies from the endometrium were taken from group 1. Biopsies from parietal peritoneum and endometrium were taken from group 2. Results showed VEGF immunoreactivity of peritoneal biopsies of group 1 was more intense than that of the control biopsies. A positive correlation was seen between the diameter of cyst capsules and VEGF labeling intensity and as the size of cyst enlarged, the appearance of non-homogeneous distribution of VEGF immunolocalization became more frequent. We conclude that the variation of VEGF immunolocalization in endometrioma cysts may be attributed to other possible angiogenic molecules in the pathogenesis and may cause unexpected responses to anti-angiogenic therapies.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Ovarian Cysts Vascular Endothelial Growth Factor A Adult Endometriosis Endometriosis Female Humans Immunohistochemistry Ovarian Cysts Ovarian Cysts Ovarian Cysts Vascular Endothelial Growth Factor A

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