Expression of the TFDP1 gene in the endometrium of women with deep infiltrating endometriosis

Jibrim RLM, Rodrigo Lopes Meime Jibrim, Cristina Valletta de Carvalho, de Carvalho CV, Adriana Luckow Invitti, Nogueira, Adriana, Eduardo Schor, Schor E
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 35(6) , pp. 490–493 · doi:10.1080/09513590.2018.1540569 · PMID:30638096 · W2909568965
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This study found that TFDP1 gene expression was downregulated in endometrial cells from women with deep infiltrating endometriosis compared to controls.

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Abstract

The field of endometriosis etiopathogenesis aims to identify the origin of disease in endometrial disorders. Changes in gene and protein expression related to cell adhesion, collagenases, and, mainly, cell cycle regulators have been identified. We set out to analyze the expression of the transcription factor DP-1 (TFDP1) gene, which encodes a protein that controls the G1/S phase passage of the cell cycle, in the endometrium of women with deep infiltrating endometriosis (DIE). Samples of endometrium from both endometriosis-affected women and healthy women were collected, cultured and maintained at the Cell Bank of the Pelvic Pain and Endometriosis Unit of the Federal University of Sao Paulo. This study analyzed five samples from the endometrium cell culture of healthy patients (i.e. no pelvic disease, as determined by means of laparoscopic tubal ligation) and six samples from women diagnosed with DIE. Samples were evaluated for TFDP1 gene expression by real-time PCR. We observed a downregulation of TFDP1 in the endometrium cells of women with DIE when compared to the control (a fold-change of -2.05, p value=.011). The TFDP1 gene is part of the cell cycle pathway, but its function is not yet clear. Additional studies are necessary to clarify the function of TFDP1 in endometriosis etiopathogenesis.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Endometrium Peritoneal Diseases Transcription Factor DP1 Adult Down-Regulation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Transcription Factor DP1 Transcription Factor DP1

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