P27Kip1 is down-regulated in the endometrium of women with endometriosis

Eduardo Schor, Schor E, Ismael Dale C. G. Silva, da Silva ID, Ismael Dale C G da Silva, Hélio Sato, Sato H, Baracat EC, Edmund C Baracat, Edmund Chada Baracat, Manoel João B C Girão, Girão Mj, de Freitas V, Vilmon de Freitas
Fertility and sterility · 2008 · vol. 91(3) , pp. 682–686 · doi:10.1016/j.fertnstert.2007.12.070 · PMID:18321488 · W2073045511
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the expression of P27Kip1 in endometrial tissue and found that its levels are decreased in women diagnosed with endometriosis.

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Abstract

ObjectiveTo evaluate p27 protein expression in the endometrium of women with endometriosis.DesignTransversal case-control study.SettingEndometriosis Unit, Federal University of São Paulo, Brazil.Patient(s)Thirteen patients with stage I/II endometriosis, five with stage III/IV endometriosis, and 11 control subjects.Intervention(s)Endometrial biopsies were obtained from patients with proven endometriosis and women without disease at laparoscopy. P27 protein was immunolocalized in the biopsy tissues and quantified by light microscopy.Main outcome measure(s)Immunostaining scores of glandular and stromal cells in endometrial biopsies obtained from patients with confirmed endometriosis compared with those of healthy control women with normal pelvis at laparoscopy. The staining scores of stage I/II and stage III/IV patients and of both patient groups and the control group were compared.Result(s)The level of p27 protein expression observed in the control group, both in the stroma and in the endometrial glands, was significantly different from that observed in the endometriosis patient groups. Significant differences in p27 protein expression levels in the glandular epithelium and stroma were not observed among groups of patients with endometriosis.Conclusion(s)The decreased level of p27 protein in the endometrium of women with endometriosis suggests that cell cycle alterations in the endometrial mucosa may be involved in the pathogenesis of this disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Intracellular Signaling Peptides and Proteins Biopsy Case-Control Studies Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Female Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins Laparoscopy Severity of Illness Index Stromal Cells

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