RHOC: A Key Gene for Endometriosis

Juliana Meola, Daniel Blasioli Dentillo, Daniel Blassioli Dentillo, Júlio César Rosa e Silva, Gabriela dos Santos Hidalgo, Cláudia Cristina Paro de Paz, Rui Alberto Ferriani
Reproductive sciences (Thousand Oaks, Calif.) · 2013 · vol. 20(8) , pp. 998–1002 · doi:10.1177/1933719112472743 · PMID:23302395 · W2003799700
article OA: green CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

RHOC expression was significantly increased in endometriotic lesions compared to eutopic endometrium and control endometrium, suggesting its role in endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated whether RHOC gene expression differs between eutopic endometrium and endometriotic lesions in women with endometriosis, using 40 patients with endometriosis and 15 healthy fertile controls. Paired endometrial biopsies from each patient provided eutopic and ectopic (endometriotic) tissues, and RHOC expression was measured by real-time PCR in these autologous tissues and in control endometrium. RHOC expression was increased in endometriotic lesions compared with eutopic endometrium from women with endometriosis and compared with control endometrium. The paper’s main caveat is that it primarily reports differential gene expression without mechanistic experiments to establish causality for RHOC in endometriosis. This paper is centrally about endometriosis — it identifies RHOC as a gene with higher expression in endometriotic lesions versus eutopic endometrium.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Gene Expression Regulation, Enzymologic rho GTP-Binding Proteins Adult Case-Control Studies Endometriosis Endometrium Female Humans rhoC GTP-Binding Protein rho GTP-Binding Proteins RNA, Messenger RNA, Messenger Up-Regulation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (7)

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