Vascular Endothelial Growth Factor and Endometriosis

Among the endometriosis etiological studies,the theory of restrograde menstruation implantation is widely accepted.However,in recent years,scholars have found that restrograde menstruation was a common physiological phenomenon but the endometriosis incidence was much lower.And consequently they proposed that some other factors probably also play important roles in the progress of endometriosis.Currently,they found angiogenesis around the transplanted tissue was strongly associated with EMs and some of them hypothesized that menstrual backflow was only a preparation whereas the supply and maintenance of blood were major determinants.Therefore,vascular endothelial growth factor(VEGF) as the strongest angiogenic factor,has been becoming the main focus in the etiology of endometriosis.