The expression of Bcl-2 in adenomyosis and its effect on proliferation, migration, and apoptosis of endometrial stromal cells

Junyan Li, Li J, Yanyan M, Ma Yanyan, Lin Mu, Mu L, Chen X, Xuejun Chen, Wei Zheng, Zheng W
Pathology, research and practice · 2019 · vol. 215(8) , pp. 152477 · doi:10.1016/j.prp.2019.152477 · PMID:31174926 · W2946915636
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This study investigated Bcl-2 expression in adenomyosis and its impact on endometrial stromal cell proliferation, migration, and apoptosis.

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Abstract

Adenomyosis is a common gynecologic disease that severe impact on women. Previous studies have found that Bcl-2 abnormally expressed in adenomyosis. However, the exact mechanisms of Bcl-2 in the pathogenesis of adenomyosis are unclear. In this study, we are to explore the effect of Bcl-2 on proliferation, migration, and apoptosis of endometrial stromal cells. The expression of Bcl-2 were evaluated by Western blot and RT-qPCR. We used RNA interference to silence Bcl-2 gene of endometrial stromal cells, and then Cell Counting Kit(CCK-8), cell scratch repair test, and Annexin V-APC/propidium iodide (PI) staining were performed to detect the cell viability, migration ability and apoptotic rate. The results of the present study revealed that the expression of Bcl-2 was evidently higher than that in control group. After silencing the Bcl-2 gene, the cytoactive and migration ability of endometrial stromal cells of adenomyosis decreased, and the apoptotic rate increased. In conclusion, Bcl-2 is overexpressed in adenomyosis and participate in the pathogenesis of adenomyosis. Bcl-2 may be a potential novel target for adenomyosis treatment.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Apoptosis Cell Movement Proto-Oncogene Proteins c-bcl-2 Stromal Cells Adenomyosis Adenomyosis Apoptosis Cell Movement Cell Movement Cell Proliferation Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Female Humans Proto-Oncogene Proteins c-bcl-2

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