S100A7 promotes the development of human endometriosis by activating NF‐κB signaling pathway in endometrial stromal cells

Qingqing Sun, Yijuan Cao, Yonglian Lan, Lingling Lei, Bei Zhang, Shuyu Wang
Cell biology international · 2021 · vol. 45(6) , pp. 1327–1335 · doi:10.1002/cbin.11578 · PMID:33675277 · W3135145550
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S100A7 expression is increased in endometriosis and drives disease progression by promoting endometrial stromal cell proliferation, invasion, and inflammation via the NF-κB signaling pathway.

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Abstract

Endometriosis (EM) is a chronic inflammatory disease affecting women aged between 23 and 42 years with a prevalence of 6%-10%. S100A7, a member of the S100 protein family, has been implicated in promoting inflammation. However, the role of S100A7 in EM and its underlying mechanism remain to be elucidated. S100A7 was silenced or overexpressed in primary endometrial stromal cells (ESCs). Cell proliferation was determined using a Cell Counting Kit-8. Cell cycle/apoptosis was monitored using a flow cytometer. Cell invasion was studied by a Transwell assay. Quantitative RT-PCR and Western blot analyses were used to evaluate gene expression. S100A7 and NF-κB expression is increased in both endometriotic tissue and ESCs from women with EM. The expression of S100A7 is correlated with the expression of NF-κB. S100A7 knockdown inhibits ESCs proliferation, cell cycle progression, cell invasion, and inflammation, but promotes cell apoptosis in an NF-κB dependent manner. In contrast, S100A7 overexpression demonstrated an inverse effect. S100A7 is increased in both endometriotic tissue and ESCs from women with EM. S100A7 overexpression contributes to EM through increasing ESCs proliferation, cell cycle progression, cell invasion, and inflammation, and inhibiting cell apoptosis in the NF-κB dependent manner. These findings highlight the importance of S100A7/NF-κB signaling in EM and provide new insights into therapeutic strategies for EM.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelial Cells NF-kappa B S100 Calcium Binding Protein A7 Adult Cells, Cultured Endometriosis Female Gene Expression Regulation, Neoplastic Humans NF-kappa B S100 Calcium Binding Protein A7 Young Adult

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