GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil

Frare AB, Ariane Bocaletto Frare, A B Frare, A M Barbosa, Barbosa AM, Iasmim Ribeiro da Costa, Costa IR, I R Costa, S R Souza, Souza SR, R C P C Silva, Silva RC, Bordin BM, B M Bordin, Ribeiro Júnior CL, C L Ribeiro Júnior, Moura KK, K K V O Moura
Genetics and molecular research : GMR · 2013 · vol. 12(3) , pp. 2764–2770 · doi:10.4238/2013.august.2.1 · PMID:23979901 · W2146258064
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This study investigated GSTM1 and GSTT1 gene polymorphisms in women with endometriosis from Goiás, Brazil, finding a higher frequency of gene absence but no statistically significant association with endometriosis proliferation.

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Abstract

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of present/absent polymorphisms of GSTM1 and GSTT1 in 50 women diagnosed with endometriosis and in a control group of 46 women without complaints related to this pathology. The association of these polymorphisms with p53 gene codon 72 was also evaluated within each group, and a higher frequency of absence of GSTM1 (61%) and GSTT1 (45%) genes in the group of women studied, women with endometriosis and control group was found. The contributions of GSTM1 and GSTT1 polymorphisms to the proliferation of endometriosis were not statistically significant, but the analysis of pathology and the association of GSTM1 and GSTT1 gene polymorphisms with p53 codon 72 revealed statistical significance.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glutathione Transferase Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Adult Adult Brazil Brazil Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Genetic Association Studies Genetic Association Studies Glutathione Transferase Glutathione Transferase Humans Humans

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