Efficacy of Norethisterone in Patients with Ovarian Endometrioma

Taniguchi F, Fuminori Taniguchi, Akiko Enatsu, Enatsu A, Ikebuchi A, Ai Ikebuchi, Yamane E, Emiko Yamane, Moriyama M, Maako Moriyama, Jiro Murakami, Murakami J, Takashi Harada, Tasuku Harada, Harada T
Yonago acta medica · 2017 · vol. 60(3) , pp. 182–185 · doi:10.33160/yam.2017.09.008 · PMID:28959130 · PMC5611474 · W2906958655
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Treatment with norethisterone for six months reduced ovarian endometrioma size and relieved dysmenorrhea pain in six patients with endometriosis.

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This preliminary 2017 report evaluated the efficacy of norethisterone (a progestin) in 6 patients with endometriosis, focusing on changes in ovarian endometrioma size and dysmenorrhea over a 6-month treatment period. After 6 months of therapy, ovarian endometrioma size decreased, and all patients reported relief of dysmenorrhea pain within that timeframe. The paper explicitly frames the work as preliminary and provides a small case series without details on comparator groups or limitations beyond its early-report nature. This paper is centrally about endometriosis—specifically the efficacy of norethisterone in patients with ovarian endometrioma and associated dysmenorrhea.

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Abstract

Endometriosis is a chronic inflammatory disorder associated with pelvic pain and infertility. Because surgical and medical therapies control symptoms, but it is hard to cure completely endometriosis, long term of pharmacologic management is necessary. Norethisterone (NET), one of progestins, has safety profile and advantage that allow long-term use. In this preliminary report, we showed the efficacy of NET in 6 patients with endometriosis. The size of ovarian endometrioma was decreased after treatment with NET for 6 months, and all patients were relieved from dysmenorrhea pain within 6 months, suggesting that NET would be a suitable medication to treat endometriosis.
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Patient Report Efficacy of Norethisterone in Patients with Ovarian Endometrioma Norethisterone for treatment of endometriosis 2017 Volume 60 Issue 3 Pages 182-185 Details Abstract Endometriosis is a chronic inflammatory disorder associated with pelvic pain and infertility. Because surgical and medical therapies control symptoms, but it is hard to cure completely endometriosis, long term of pharmacologic management is necessary. Norethisterone (NET), one of progestins, has safety profile and advantage that allow long-term use. In this preliminary report, we showed the efficacy of NET in 6 patients with endometriosis. The size of ovarian endometrioma was decreased after treatment with NET for 6 months, and all patients were relieved from dysmenorrhea pain within 6 months, suggesting that NET would be a suitable medication to treat endometriosis. © 2017 Tottori University Faculty of Medicine Favorites & Alerts Recently viewed articles

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endometriosisendometriomadysmenorrheainfertility

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