Vascular endothelial growth factor (-460 C/T, +405 G/C, and +936 C/T) polymorphisms and endometriosis risk in Tunisian population

Henidi B, Belkis Henidi, Wajih Kaabachi, Kaabachi W, Abir Naouali, Naouali A, Safa Kaabachi, Kaabachi S, Zhioua A, Amel Zhioua, A. Zhioua, Haj Sassi F, Faycal Haj Sassi, Fayçal Haj Sassi, Hamzaoui K, Kamel Hamzaoui
Systems biology in reproductive medicine · 2015 · vol. 61(4) , pp. 238–244 · doi:10.3109/19396368.2015.1041622 · PMID:25984730 · W1879063215
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This study found that the VEGF +936 C/T polymorphism is associated with endometriosis risk, with the T allele linked to advanced stages in Tunisian women.

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Abstract

The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian population. This study includes 105 women with endometriosis and 150 women with no laparoscopic evidence of disease. Genotyping of the VEGF -460 C/T, +405 G/C, and +936 C/T polymorphisms were performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes (P = 0.006) and allele (P = 0.0009) frequencies of the +936 C/T polymorphism was significantly different between patients and controls. Patients with stages III-IV endometriosis showed a higher VEGF + 936T allele frequency than controls (P = 0.0001). However, the distribution of genotypes and allele frequencies of the VEGF -460 C/T and +405 G/C polymorphisms did not differ significantly between endometriosis patients and controls. These findings suggest that the VEGF +936 C/T polymorphism may be a risk factor for endometriosis development and the VEGF +936 T allele is associated with an increased risk of stages III-IV endometriosis in the Tunisian population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Polymorphism, Genetic Polymorphism, Genetic Vascular Endothelial Growth Factor A Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Haplotypes Haplotypes Humans Humans Tunisia Tunisia

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